Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We
report here the ability to resist to 5‐fluorouracil‐induced apoptosis of 8 colon cancer cell …

Recently, apoptosis has been implicated as one of the end points of cells exposed to
chemotherapeutic agents. The p53 and Bcl-2 family of proteins are involved in …

Abstract p53 tumour-suppressor gene is involved in cell growth control, arrest and
apoptosis. Nevertheless cell cycle arrest and apoptosis induction can be observed in p53 …

To elucidate mechanisms of resistance to chemotherapies currently used in the first-line
treatment of advanced colorectal cancer, we have developed a panel of HCT116 p53 wild …

We examined chemosensitivity to 5-fluorouracil (5-FU) in four human gastric cancer cell
lines, by analyzing the expression of p53 and its related genes. Treatment with 1mM 5-FU …

Background Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU) causes DNA
damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU …

Anticancer agents induce cancer cell death through apoptosis or necrosis. As anticancer
agents at low and high concentrations cause apoptosis and necrosis, respectively, cancer …

We examined the patterns of induction of apoptosis, Fas expression, and the influence of the
status of the p53 tumor suppressor gene, in response to treatment of human colon …

Elucidation of the molecular mechanisms by which 5‑fluorouracil (5‑FU) induces apoptosis
is required in order to understand the resistance of colorectal cancer (CRC) cells to 5‑FU. In …

Fluorouracil (5-FU) is commonly used to treat human colon cancers but resistance to this
compound is frequently observed in clinics. To characterize mechanisms of resistance to 5 …