The enzyme heme oxygenase-1 (HO-1) is pivotal in reproductive processes, particularly in
placental and vascular development. This study investigated the role of HO-1 and its …

Deletion of the heme oxygenase-1 (HO-1)(Hmox1) locus in mice results in intrauterine
lethality. The expression of the heme catabolizing enzyme encoded by this gene, namely …

Abstract Heme oxygenase 1 (Hmox1), the inducible form of heme degrading enzymes
Hmoxs, is important for establishment and maintenance of pregnancy. A growing body of …

Background Pregnancy is characterized by an inflammatory-like process and this may be
exacerbated in preeclampsia. The heme oxygenase (HO) enzymes generate carbon …

Heme oxygenase 1 (HO-1, encoded by the HMOX1 gene) is the rate-limiting enzyme that
catalyzes heme degradation, and it has been reported to exert antioxidative effects …

The onset of pregnancy implies the appearance of a new organ, the placenta. One main
function of the placenta is to supply oxygen to the fetus via hemoproteins. In this review, we …

We previously confirmed that Nuclear factor erythroid 2-related factor-2 (Nrf2) and heme
oxygenase (HO-1) play synergistic roles in the pathogenesis of preeclampsia. To further …

Citation Zenclussen ML, Jensen F, Rebelo S, El‐Mousleh T, Casalis PA, Zenclussen AC.
Heme oxygenase‐1 expression in the ovary dictates a proper oocyte ovulation, fertilization …

Problem Sterile inflammation through activation of cytokine receptor signalling pathways
and viral or bacterial infection via activation of Toll‐like receptors (TLR s) induces a cascade …

Infiltrating myeloid cells in pregnant uteri play critical roles in the establishment of the
placenta and maintenance of normal pregnancies. Their recruitment and proliferation are …