Comprehensive Approach to Cancer Immunotherapy–Simultaneous Targeting of Myeloid-derived Suppressor Cells and Cancer Cells with AFP Conjugates

VN Pak, IA Sherman - Critical Reviews in Oncology/Hematology, 2024 - Elsevier
The immune system plays a pivotal role in combating diseases, including cancer, with
monocytes emerging as key regulators of immune response dynamics. This article describes …

[HTML][HTML] Selective targeting of myeloid-derived suppressor cells in cancer patients through AFP-binding receptors

VN Pak - Future Science OA, 2019 - Taylor & Francis
In theory, a mother during pregnancy (especially a surrogate mother) is 'infected'by an alien
embryo, yet her immune system does not reject it. The fetus and placenta express antigens …

523P AFP-maytansine conjugate: A novel targeted cancer immunotherapy

IA Sherman, R Boohaker, K Stinson… - Annals of …, 2021 - annalsofoncology.org
Background The alpha fetoprotein (AFP) receptor is an oncofetal antigen and a novel target
for cancer therapeutics, This receptor is highly expressed on the surface of common cancers …

Efficacy and safety study of a novel alpha-fetoprotein (AFP)-maytansine conjugate in an ovarian xenograft model.

IA Sherman, W Hill, P Griffin, D Andrews, RJ Boohaker… - 2023 - ascopubs.org
e14570 Background: AFP receptor is an oncofetal antigen and a novel target for cancer
therapeutics. It is highly expressed on the surfaces of many cancers and Myeloid Derived …

[PDF][PDF] Achilles heel of cancer

V Pak - Cancer Therapy & Oncol. Int. J, 2017 - researchgate.net
Immunotherapy is the most promising trend in cancer treatments. Checkpoint inhibitors block
the blocking molecules, enabling T-cells to target the cancer. MDSC-targeted …

Treatment of hematologic malignancies with immunotoxins and antibody-drug conjugates

DJ FitzGerald, AS Wayne, RJ Kreitman, I Pastan - Cancer research, 2011 - AACR
To enable antibodies to function as cytotoxic anticancer agents, they are modified either via
attachment to protein toxins or highly potent, low-molecular-weight drugs. Such molecules …

[PDF][PDF] Magic bullet and immunotherapy against metastasis

V Pak - J. Cancer Prev. Curr. Res, 2016 - researchgate.net
Cancer is uncontrolled cell proliferation. Apoptosis controls the cells from inside while
immune system controls the cells from outside. Cancer breaks both controls. To treat cancer …

An alpha-fetoprotein-maytansine conjugate for the treatment of AFP receptor expressing tumors.

IA Sherman, RJ Boohaker, K Stinson, P Griffin, W Hill - 2022 - ascopubs.org
e15056 Background: The alpha fetoprotein (AFP) receptor is an oncofetal antigen and a
novel target for cancer therapeutics. It is highly expressed on the surfaces of many cancers …

[HTML][HTML] The possible drug for cancer and metastasis prevention

VN Pak - Future Drug Discovery, 2022 - Taylor & Francis
One in two people will be diagnosed with cancer in their lifetime in developed countries.
Prophylactics and early diagnostics are recommended to everyone. On the other hand, even …

Immunotoxins and antibody-drug conjugates for cancer treatment

VS Goldmacher, WA Blättler, JM Lambert… - Biomedical aspects of …, 2002 - Springer
A large number of cytotoxic compounds are currently used as chemotherapeutic drugs to
treat various malignancies. In general, the therapeutic efficacy of these drugs is limited by …