Maternal diabetes leads to unphysiological high lipid accumulation in rabbit preimplantation embryos
M Schindler, M Pendzialek, A Navarrete Santos… - …, 2014 - academic.oup.com
According to the “developmental origin of health and disease” hypothesis, the metabolic set
points of glucose and lipid metabolism are determined prenatally. In the case of a diabetic …
points of glucose and lipid metabolism are determined prenatally. In the case of a diabetic …
Cholesterol metabolism in rabbit blastocysts under maternal diabetes
SM Pendzialek, M Schindler, T Plösch… - Reproduction …, 2017 - CSIRO Publishing
In the rabbit reproductive model, maternal experimentally induced insulin-dependent
diabetes mellitus (expIDD) leads to accumulation of lipid droplets in blastocysts. Cholesterol …
diabetes mellitus (expIDD) leads to accumulation of lipid droplets in blastocysts. Cholesterol …
[HTML][HTML] Ectopic Lipid Accumulation Correlates with Cellular Stress in Rabbit Blastocysts from Diabetic Mothers
M Schindler, SM Geisler, T Seeling… - International Journal of …, 2023 - mdpi.com
Maternal diabetes mellitus in early pregnancy leads to hyperlipidemia in reproductive tract
organs and an altered embryonic environment. To investigate the consequences on …
organs and an altered embryonic environment. To investigate the consequences on …
Embryonic fatty acid metabolism in diabetic pregnancy: the difference between embryoblasts and trophoblasts
M Schindler, D Dannenberger… - Molecular human …, 2020 - academic.oup.com
During the first days of development the preimplantation embryo is supplied with nutrients
from the surrounding milieu. Maternal diabetes mellitus affects the uterine …
from the surrounding milieu. Maternal diabetes mellitus affects the uterine …
A short periconceptional exposure to maternal type-1 diabetes is sufficient to disrupt the feto-placental phenotype in a rabbit model
D Rousseau-Ralliard, A Couturier-Tarrade… - Molecular and cellular …, 2019 - Elsevier
Tight metabolic control of type-1 diabetes is essential during gestation, but it could be crucial
during the periconception period. Feto-placental consequences of maternal type-1 diabetes …
during the periconception period. Feto-placental consequences of maternal type-1 diabetes …
Dynamic regulation of lipid metabolism in the placenta of in vitro and in vivo models of gestational diabetes mellitus
SY Kim, YJ Lee, SM An, MJ Kim, JS Jeong… - Biology of …, 2022 - academic.oup.com
The purpose of this study was to investigate lipid metabolism in the placenta of gestational
diabetes mellitus individuals and to evaluate its effect on the fetus. We examined the …
diabetes mellitus individuals and to evaluate its effect on the fetus. We examined the …
[HTML][HTML] Species and embryo genome origin affect lipid droplets in preimplantation embryos
P Lipinska, P Pawlak, E Warzych - Frontiers in Cell and …, 2023 - frontiersin.org
Mammalian embryo development is affected by multiple metabolism processes, among
which energy metabolism seems to be crucial. Therefore the ability and the scale of lipids …
which energy metabolism seems to be crucial. Therefore the ability and the scale of lipids …
Lipid metabolism in the embryos of diabetic rats during early organogenesis: modulatory effect of prostaglandin E2
D Sinner, JM Caviglia, A Jawerbaum… - Reproduction …, 2003 - CSIRO Publishing
The purpose of this work was to evaluate de novo lipid biosynthesis and the lipid profile, and
to study the effect of prostaglandin E2 (PGE2; prostaglandin has previously been found to be …
to study the effect of prostaglandin E2 (PGE2; prostaglandin has previously been found to be …
Maternal dietary glucose-lipid interactions modulate embryological development in vivo and in embryo culture
S Kubow, KG Koski - Biology of reproduction, 1995 - academic.oup.com
To examine the dietary interrelationships of glucose and lipid on embryological growth and
development, two levels of glucose (0% and 24%) and two types of lipid—soybean oil (SBO; …
development, two levels of glucose (0% and 24%) and two types of lipid—soybean oil (SBO; …
Lipid metabolism in the fetus and the newborn
E Herrera, E Amusquivar - Diabetes/metabolism research and …, 2000 - Wiley Online Library
During late gestation, although maternal adipose tissue lipolytic activity becomes enhanced,
lipolytic products cross the placenta with difficulty. Under fasting conditions, free fatty acids …
lipolytic products cross the placenta with difficulty. Under fasting conditions, free fatty acids …