DNA damage by endogenous and exogenous agents is a serious concern, as the damaged
products can affect genome integrity severely. Damage to DNA may arise from various …

Among the natural bases, guanine is the most oxidizable base. The damage caused by
oxidation of guanine, commonly referred to as oxidative guanine damage, results in the …

Of the four native nucleosides, 2′-deoxyguanosine (dGuo) is most easily oxidized. Two
lesions derived from dGuo are 8-oxo-7, 8-dihydro-2′-deoxyguanosine (8-oxodGuo) and 2 …

DNA is continuously attacked by reactive species that can affect its structure and function
severely. Structural modifications to DNA mainly arise from modifications in its bases that …

Guanine is the most readily oxidized of the four DNA bases, and guanine oxidation products
cause G: CT: A and G: CC: G transversions through DNA replication. 8-Oxo-7, 8 …

Recent evidence suggests that salvage of 8-oxo-7, 8-dihydro-2′-deoxyguanosine (8-
oxodG) and 8-oxo-7, 8-dihydro-guanine (8-oxoGua) can contribute substantially to levels of …

The one-electron oxidation product of guanine, 8-oxo-7, 8-dihydroguanine (8-oxoG), is an
abundant lesion in genomic, mitochondrial, and telomeric DNA and RNA. It is considered to …

Oxidatively produced DNA damage is a physiological process that has been associated with
many human conditions. Of the four DNA bases, guanine is the most easily oxidized and …

Emphasis is placed in the first part of this survey on mechanistic aspects of the formation of 8-
oxo-7, 8-dihydroguanine (8-oxoGua) as the result of exposure to OH radical, one-electron …

Guanine oxidation occurs in both DNA and the cellular nucleotide pool, and one of the major
products is 8-hydroxyguanine (8-oxo-7, 8-dihydroguanine). The mutagenic potentials of this …