ContextAlcohol dependence treatment may include medications, behavioral therapies, or
both. It is unknown how combining these treatments may impact their effectiveness …

Objective: The aim of this study was to examine the efficacy of pharmacological and
behavioral interventions across 1 year posttreatment in the COMBINE (Combining …

Background: Medications (such as naltrexone and acamprosate) as well as behavioral
therapies have been previously reported to be effective in the reduction of alcohol intake …

Increasing knowledge about effective therapies for alcohol dependence calls for new
research designs to examine treatment interactions between pharmacotherapies and …

Objective: To summarize published data on pharmacologic treatments for alcohol
dependence alone and in combination with brief psychosocial therapies that may be …

ContextAlcoholism affects approximately 10% of Americans at some time in their lives.
Treatment consists of psychosocial interventions, pharmacological interventions, or both, but …

Importance Alcohol use disorders cause substantial morbidity and early mortality yet remain
greatly undertreated. Medications are considerably underused. Objective To conduct a …

Aims: To compare treatment outcomes amongst patients offered pharmacotherapy with
either naltrexone or acamprosate used singly or in combination, in a 12-week outpatient …

ContextAlcohol dependence is a common disorder associated with significant morbidity and
mortality. Naltrexone, an opioid antagonist, has been shown to be effective for treatment of …

Aims Although debates over the efficacy of oral naltrexone and acamprosate in treating
alcohol use disorders tend to focus on their global efficacy relative to placebo or their …