Updates on Disease Mechanisms and Therapeutics for Amyotrophic Lateral Sclerosis
L Nguyen - Cells, 2024 - mdpi.com
Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a motor neuron disease. In
ALS, upper and lower motor neurons in the brain and spinal cord progressively degenerate …
ALS, upper and lower motor neurons in the brain and spinal cord progressively degenerate …
[HTML][HTML] Risk factors and emerging therapies in amyotrophic lateral sclerosis
N Nowicka, J Juranek, JK Juranek… - International journal of …, 2019 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease
characterized by a permanent degeneration of both upper and lower motor neurons. Many …
characterized by a permanent degeneration of both upper and lower motor neurons. Many …
Progress in amyotrophic lateral sclerosis gene discovery: reflecting on classic approaches and leveraging emerging technologies
SN Smukowski, H Maioli, CS Latimer, TD Bird… - Neurology …, 2022 - AAN Enterprises
Amyotrophic lateral sclerosis (ALS) is the most prominent motor neuron disease in humans.
Its etiology consists of progressive motor neuron degeneration resulting in a rapid decline in …
Its etiology consists of progressive motor neuron degeneration resulting in a rapid decline in …
Advances in the development of disease-modifying treatments for amyotrophic lateral sclerosis
D Moujalled, AR White - CNS drugs, 2016 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive adult-onset, neurodegenerative disease
characterized by the degeneration of upper and lower motor neurons. Over recent years …
characterized by the degeneration of upper and lower motor neurons. Over recent years …
[引用][C] Recent advances in the pathogenesis and therapeutics of amyotrophic lateral sclerosis
J Fernández‐Ruiz, E de Lago… - British Journal of …, 2021 - Wiley Online Library
Amyotrophic lateral sclerosis (ALS) is a progressive and highly disabling neurodegenerative
disorder, with an incidence of 1–5 cases/100,000 subjects and characterized by muscle …
disorder, with an incidence of 1–5 cases/100,000 subjects and characterized by muscle …
[HTML][HTML] Sporadic and hereditary amyotrophic lateral sclerosis (ALS)
S Ajroud-Driss, T Siddique - … et Biophysica Acta (BBA)-Molecular Basis of …, 2015 - Elsevier
Genetic discoveries in ALS have a significant impact on deciphering molecular mechanisms
of motor neuron degeneration. The identification of SOD1 as the first genetic cause of ALS …
of motor neuron degeneration. The identification of SOD1 as the first genetic cause of ALS …
[HTML][HTML] RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse
Mechanisms involved with degeneration of motor neurons in amyotrophic lateral sclerosis
(ALS; Lou Gehrig's Disease) are poorly understood, but genetically inherited forms …
(ALS; Lou Gehrig's Disease) are poorly understood, but genetically inherited forms …
Genetic determinants of amyotrophic lateral sclerosis as therapeutic targets
DA Bosco, JE Landers - CNS & Neurological Disorders-Drug …, 2010 - ingentaconnect.com
Amyotrophic lateral sclerosis (ALS) is an incurable disease resulting from the deterioration
of motor neurons. The onset of disease typically occurs in the fifth decade of life and …
of motor neurons. The onset of disease typically occurs in the fifth decade of life and …
Emerging understanding of the genotype–phenotype relationship in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a progressive, noncurable neurodegenerative
disorder of the upper and lower motor neurons causing weakness and death within a few …
disorder of the upper and lower motor neurons causing weakness and death within a few …
State of play in amyotrophic lateral sclerosis genetics
Considerable progress has been made in unraveling the genetic etiology of amyotrophic
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …
lateral sclerosis (ALS), the most common form of adult-onset motor neuron disease and the …