Pain from surgical procedures occurs as a consequence of tissue trauma and may result in
physical, cognitive, and emotional discomfort. Almost a century ago, researchers first …

Extending a multimodal analgesic treatment into the postoperative period to prevent
postoperative pain may be superior compared with preemptive analgesia. In the future …

The classic definition of preemptive analgesia requires 2 groups of patients to receive
identical treatment before or after incision or surgery. The only difference between the 2 …

IMPLICATIONS: This meta-analysis assesses the ability of preemptive analgesic
interventions to attenuate postoperative pain scores, decrease supplemental postoperative …

Preemptive analgesia means that an analgesic intervention is started before the noxious
stimulus arises in order to block peripheral and central nociception. This afferent blockade of …

Studies that used a preventive design had a greater likelihood of finding a beneficial effect.
The application of preventive perioperative analgesia (not necessarily preincisional) is …

THE concept of preemptive analgesia to reduce the magnitude and duration of
postoperative pain was paved in 1983 by Woolf, 1 who showed evidence for a central …

Although some studies of pre-emptive analgesia have reported small reductions in post-
operative pain or analgesic consumption in favour of pre-incisional vs. post-incisional or …

Transmission of pain signals evoked by tissue damage leads to sensitization of the
peripheral and central pain pathways. Pre-emptive analgesia is a treatment that is initiated …

Pain, which is often inadequately treated, accompanies the more than 23 million surgical
procedures performed each year and may persist long after tissue heals. Preemptive …