Breast and other estrogen receptor α-positive cancers tend to develop resistance to existing
drugs. Chalcone derivatives possess anticancer activity based on their ability to form …

Chalcones are valuable structures for drug discovery due to their broad bioactivity spectrum.
In this study, we evaluated 20 synthetic chalcones against estrogen-receptor-positive breast …

This study aimed to determine the in vitro cytotoxicity and understand possible cytotoxic
mechanisms via an in silico study of eleven chalcones synthesized from two …

A series of novel-substituted chalcone analogs were synthesized and evaluated for
antiproliferative activity against estrogen receptor-positive MCF-7 breast cancer cell lines …

Chalcones are interesting anticancer drug candidates which have attracted much interest
due to their unique structure and their extensive biological activity. Various functional …

Chalcones are a group with recognized biological potential against many diseases,
including cancer. Thus, studies on these structure have become an attractive chemical …

Conspectus The study discussed herein describes the synthesis of halogenated chalcones
as potential chemotherapeutics. The synthesis work was conducted by undergraduate …

Cancer treatment still requires new compounds to be discovered. Chalcone and its
derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran …

Chalcones are small molecules, naturally found in fruits and vegetables, and exhibit diverse
pharmacological activities. They also possess anticancer activity against different tumors …

Twenty-seven new ortho-hydroxy chalcone and a series of indole-chalcone derivatives have
been designed and synthesized. The structures of all newly-synthesized compounds were …