Rhinovirus induces airway remodeling: what are the physiological consequences?

C Spector, CM De Sanctis, RA Panettieri Jr… - Respiratory …, 2023 - Springer
Background Rhinovirus infections commonly evoke asthma exacerbations in children and
adults. Recurrent asthma exacerbations are associated with injury-repair responses in the …

Remodeling of bronchial epithelium caused by asthmatic inflammation affects its response to rhinovirus infection

B Jakiela, A Rebane, J Soja, S Bazan-Socha… - Scientific reports, 2021 - nature.com
Human rhinoviruses (HRV) are frequent cause of asthma exacerbations, however the
influence of airway inflammation on the severity of viral infection is poorly understood. Here …

Rhinovirus‐induced exacerbations of asthma and COPD

MB Hershenson - Scientifica, 2013 - Wiley Online Library
Over the past two decades, increasing evidence has shown that, in patients with chronic
airways disease, viral infection is the most common cause of exacerbation. This review will …

Role of human rhinovirus in triggering human airway epithelial-mesenchymal transition

DM Minor, D Proud - Respiratory research, 2017 - Springer
Background Structural changes in the airways, collectively referred to as airway remodeling,
are a characteristic feature of asthma, and are now known to begin in early life. Human …

[PDF][PDF] Role of rhinovirus infections in asthma

D Proud - Asian Pacific journal of allergy and immunology, 2011 - apjai-journal.org
Human rhinoviruses are not only the main pathogens responsible for the common cold, but
are now recognized to have a major impact on asthma pathogenesis. There is evidence that …

Remember the Airway Smooth Muscle! How Rhinovirus Impairs Bronchodilator Responses

Y Li, MB Hershenson - American Journal of Respiratory Cell and …, 2023 - atsjournals.org
Remember the smooth muscle cell? Most cases of asthma are due to allergic inflammation.
Inflammatory cells release pro-inflammatory cytokines and other mediators which induce …

Rhinovirus infection induces extracellular matrix protein deposition in asthmatic and nonasthmatic airway smooth muscle cells

C Kuo, S Lim, NJC King, SL Johnston… - … of Physiology-Lung …, 2011 - journals.physiology.org
Airway remodeling, which includes increases in the extracellular matrix (ECM), is a
characteristic feature of asthma and is correlated to disease severity. Rhinovirus (RV) …

Rhinovirus C15 attenuates relaxation and cAMP production in human airways and smooth muscle

EB Gebski, V Parikh, H Lam, N Kim… - American journal of …, 2023 - atsjournals.org
Rhinoviruses (RVs) evoke as many as 85% of acute asthma exacerbations in children and
50% in adults and can induce airway hyperresponsiveness and decrease efficacy of current …

Impaired airway epithelial cell responses from children with asthma to rhinoviral infection

A Kicic, PT Stevens, EN Sutanto… - Clinical & …, 2016 - Wiley Online Library
Background The airway epithelium forms an effective immune and physical barrier that is
essential for protecting the lung from potentially harmful inhaled stimuli including viruses …

Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features

CL Skevaki, S Psarras, E Volonaki, H Pratsinis… - Clinical and translational …, 2012 - Springer
Background Human rhinoviruses, major precipitants of asthma exacerbations, induce lower
airway inflammation and mediate angiogenesis. The purpose of this study was to assess the …