Background Rhinovirus infections commonly evoke asthma exacerbations in children and
adults. Recurrent asthma exacerbations are associated with injury-repair responses in the …

Human rhinoviruses (HRV) are frequent cause of asthma exacerbations, however the
influence of airway inflammation on the severity of viral infection is poorly understood. Here …

Over the past two decades, increasing evidence has shown that, in patients with chronic
airways disease, viral infection is the most common cause of exacerbation. This review will …

Background Structural changes in the airways, collectively referred to as airway remodeling,
are a characteristic feature of asthma, and are now known to begin in early life. Human …

Human rhinoviruses are not only the main pathogens responsible for the common cold, but
are now recognized to have a major impact on asthma pathogenesis. There is evidence that …

Remember the smooth muscle cell? Most cases of asthma are due to allergic inflammation.
Inflammatory cells release pro-inflammatory cytokines and other mediators which induce …

Airway remodeling, which includes increases in the extracellular matrix (ECM), is a
characteristic feature of asthma and is correlated to disease severity. Rhinovirus (RV) …

Rhinoviruses (RVs) evoke as many as 85% of acute asthma exacerbations in children and
50% in adults and can induce airway hyperresponsiveness and decrease efficacy of current …

Background The airway epithelium forms an effective immune and physical barrier that is
essential for protecting the lung from potentially harmful inhaled stimuli including viruses …

Background Human rhinoviruses, major precipitants of asthma exacerbations, induce lower
airway inflammation and mediate angiogenesis. The purpose of this study was to assess the …