Abstract Background and Objective The use of an opportunistic (also called scavenged)
sampling strategy in a prospective pharmacokinetic study combined with population …

Ciprofloxacin is used in neonates with suspected or documented Gram-negative serious
infections. Currently, its use is off-label partly because of lack of pharmacokinetic studies …

Pharmacokinetic (PK) studies in preterm infants are rarely conducted due to the research
challenges posed by this population. To overcome these challenges, minimal-risk methods …

Objectives: Piperacillin is often used in preterm infants for intra-abdominal infections;
however, dosing has been derived from small single-center studies excluding extremely …

Selection of the first dose for neonates in clinical trials is very challenging. The objective of
this analysis was to assess if a population pharmacokinetic (PK) model developed with data …

The objective of this study was to characterize ciprofloxacin population pharmacokinetics in
pediatric patients. A total of 150 pediatric patients (including 28 patients with cystic fibrosis …

A number of barriers and challenges must be overcome in order to conduct the
pharmacokinetic studies that are urgently needed to inform the selection and dosing of …

The pharmacokinetics and pharmacodynamics of drugs are different in adult and paediatric
populations, the latter being particularly heterogeneous. These differences in …

The aim of the present study was to characterize the population pharmacokinetics of
ciprofloxacin in patients with and without cystic fibrosis ranging in age from 1 day to 24 years …

Background Population pharmacokinetic evaluations have been widely used in neonatal
pharmacokinetic studies, while machine learning has become a popular approach to solving …