Bioengineered human colon organoids with in vivo-like cellular complexity and function
Organoids and organs-on-a-chip have emerged as powerful tools for modeling human gut
physiology and disease in vitro. Although physiologically relevant, these systems often lack …
physiology and disease in vitro. Although physiologically relevant, these systems often lack …
Bioengineered human colon organoids with in vivo-like complexity and function
Organoids and microphysiological systems, such as organs-on-a-chip, have emerged as
powerful tools for modeling human gut physiology and disease in vitro. However, although …
powerful tools for modeling human gut physiology and disease in vitro. However, although …
Human intestinal organoids maintain self-renewal capacity and cellular diversity in niche-inspired culture condition
M Fujii, M Matano, K Toshimitsu, A Takano, Y Mikami… - Cell stem cell, 2018 - cell.com
Cellular diversity that shapes tissue architecture and function is governed by multiple niche
signals. Nonetheless, maintaining cellular diversity in human intestinal organoids has been …
signals. Nonetheless, maintaining cellular diversity in human intestinal organoids has been …
Expanding the Tissue Toolbox: Deriving Colon Tissue from Human Pluripotent Stem Cells
L Bruens, HJG Snippert - Cell Stem Cell, 2017 - cell.com
Organoid technology holds great potential for disease modeling and regenerative medicine.
In this issue of Cell Stem Cell, Múnera et al.(2017) establish the generation of pluripotent …
In this issue of Cell Stem Cell, Múnera et al.(2017) establish the generation of pluripotent …
[HTML][HTML] Enhanced utilization of induced pluripotent stem cell–derived human intestinal organoids using microengineered chips
MJ Workman, JP Gleeson, EJ Troisi, HQ Estrada… - Cellular and molecular …, 2018 - Elsevier
Background and Aims Human intestinal organoids derived from induced pluripotent stem
cells have tremendous potential to elucidate the intestinal epithelium's role in health and …
cells have tremendous potential to elucidate the intestinal epithelium's role in health and …
Stem cell-derived intestinal organoids: a novel modality for IBD
C Tian, M Yang, H Xu, M Zhu, NN Yue, Y Zhang… - Cell Death …, 2023 - nature.com
The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …
Intestinal stem cells to advance drug development, precision, and regenerative medicine: a paradigm shift in translational research
Recent advances in our understanding of the intestinal stem cell niche and the role of key
signaling pathways on cell growth and maintenance have allowed the development of fully …
signaling pathways on cell growth and maintenance have allowed the development of fully …
Technological advances and challenges in constructing complex gut organoid systems
L Zheng, Y Zhan, C Wang, Q Fan, D Sun… - Frontiers in Cell and …, 2024 - frontiersin.org
Recent advancements in organoid technology have heralded a transformative era in
biomedical research, characterized by the emergence of gut organoids that replicate the …
biomedical research, characterized by the emergence of gut organoids that replicate the …
Generation of human colon organoids from healthy and inflammatory bowel disease mucosa
I Dotti, A Mayorgas, A Salas - PloS one, 2022 - journals.plos.org
Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases (IBD) of
unknown cause characterized by a relapsing-remitting behavior. Growing evidence supports …
unknown cause characterized by a relapsing-remitting behavior. Growing evidence supports …
Combining human organoids and organ-on-a-chip technology to model intestinal region-specific functionality
The intestinal mucosa is a complex physical and biochemical barrier that fulfills a myriad of
important functions. It enables the transport, absorption, and metabolism of nutrients and …
important functions. It enables the transport, absorption, and metabolism of nutrients and …