Organoids and organs-on-a-chip have emerged as powerful tools for modeling human gut
physiology and disease in vitro. Although physiologically relevant, these systems often lack …

Organoids and microphysiological systems, such as organs-on-a-chip, have emerged as
powerful tools for modeling human gut physiology and disease in vitro. However, although …

Cellular diversity that shapes tissue architecture and function is governed by multiple niche
signals. Nonetheless, maintaining cellular diversity in human intestinal organoids has been …

Organoid technology holds great potential for disease modeling and regenerative medicine.
In this issue of Cell Stem Cell, Múnera et al.(2017) establish the generation of pluripotent …

Background and Aims Human intestinal organoids derived from induced pluripotent stem
cells have tremendous potential to elucidate the intestinal epithelium's role in health and …

The organoids represent one of the greatest revolutions in the biomedical field in the past
decade. This three-dimensional (3D) micro-organ cultured in vitro has a structure highly …

Recent advances in our understanding of the intestinal stem cell niche and the role of key
signaling pathways on cell growth and maintenance have allowed the development of fully …

Recent advancements in organoid technology have heralded a transformative era in
biomedical research, characterized by the emergence of gut organoids that replicate the …

Ulcerative colitis and Crohn's disease are chronic inflammatory bowel diseases (IBD) of
unknown cause characterized by a relapsing-remitting behavior. Growing evidence supports …

The intestinal mucosa is a complex physical and biochemical barrier that fulfills a myriad of
important functions. It enables the transport, absorption, and metabolism of nutrients and …