Analysis of Gene Expression Networks in Primary Central Nervous System Tumors for Drug Repurposing Prospects
Primary central nervous system and brain tumors are one of the global burdens that are
continuously increasing in cases and requiring more treatment options. Surgery has been …
continuously increasing in cases and requiring more treatment options. Surgery has been …
New drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing
Background Atypical meningiomas are common central nervous system neoplasms with
high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical …
high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical …
Data-driven prioritization and preclinical evaluation of therapeutic targets in glioblastoma
CG Brahm, UK Abdul, M Houweling… - Neuro-oncology …, 2020 - academic.oup.com
Background Patients with glioblastoma (GBM) have a dismal prognosis, and there is an
unmet need for new therapeutic options. This study aims to identify new therapeutic targets …
unmet need for new therapeutic options. This study aims to identify new therapeutic targets …
Proteomic Landscape of Primary and Metastatic Brain Tumors for Heterogeneity Discovery
X Liu, S Yang, C Zhou, L Zhang, Y Xiong… - Available at SSRN … - papers.ssrn.com
Brain tumors, whether primary or secondary, have limited information about proteomic
changes despite advances in understanding the driver gene mutation and heterogeneity …
changes despite advances in understanding the driver gene mutation and heterogeneity …
Metabolic modeling-based drug repurposing in Glioblastoma
C Tomi-Andrino, A Pandele, K Winzer, J King… - Scientific reports, 2022 - nature.com
The manifestation of intra-and inter-tumor heterogeneity hinders the development of
ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type …
ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type …
Identification of a novel eighteen-gene signature of recurrent metastasis neuroblastoma
S Zhang, R Jiang, M Yang, T Wang, H Chen… - Journal of Molecular …, 2023 - Springer
Neuroblastoma is the most common malignant tumor in childhood, and metastases occur in
more than 30% patients. Recurrent metastasis is the main cause of poor prognosis and high …
more than 30% patients. Recurrent metastasis is the main cause of poor prognosis and high …
Integrating Multi-Omics analysis for enhanced diagnosis and treatment of glioblastoma: A comprehensive Data-Driven approach
A Barzegar Behrooz, H Latifi-Navid, SC da Silva Rosa… - Cancers, 2023 - mdpi.com
Simple Summary The most prevalent and lethal primary brain tumor, glioblastoma
multiforme (GBM), exhibits fast growth and widespread invasion and has a poor prognosis …
multiforme (GBM), exhibits fast growth and widespread invasion and has a poor prognosis …
Identification of novel therapeutic targets in glioblastoma with functional genomic mRNA profiling.
CG Brahm, AME Walenkamp, ME Van Linde… - 2017 - ascopubs.org
2018 Background: Glioblastoma (GBM), the most common primary brain tumor in adults,
universally recurs and has a dismal prognosis. Therefore, there is an unmet need for new …
universally recurs and has a dismal prognosis. Therefore, there is an unmet need for new …
Rembrandt: helping personalized medicine become a reality through integrative translational research
S Madhavan, JC Zenklusen, Y Kotliarov, H Sahni… - Molecular cancer …, 2009 - AACR
Finding better therapies for the treatment of brain tumors is hampered by the lack of
consistently obtained molecular data in a large sample set and the ability to integrate …
consistently obtained molecular data in a large sample set and the ability to integrate …
[HTML][HTML] Proteogenomic characterization and integrative analysis of glioblastoma multiforme
YC Song, GX Lu, HW Zhang, XM Zhong, XL Cong… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM), the most aggressive and lethal primary brain tumor, is
characterized by very low life expectancy. Understanding the genomic and proteogenomic …
characterized by very low life expectancy. Understanding the genomic and proteogenomic …