Analysis of Gene Expression Networks in Primary Central Nervous System Tumors for Drug Repurposing Prospects

BHA Villanueva, PW Tsai, LL Tayo - 2023 - preprints.org
Primary central nervous system and brain tumors are one of the global burdens that are
continuously increasing in cases and requiring more treatment options. Surgery has been …

New drug candidates for treatment of atypical meningiomas: An integrated approach using gene expression signatures for drug repurposing

Z Zador, AT King, N Geifman - PLoS One, 2018 - journals.plos.org
Background Atypical meningiomas are common central nervous system neoplasms with
high recurrence rate and poorer prognosis compared to their grade I counterparts. Surgical …

Data-driven prioritization and preclinical evaluation of therapeutic targets in glioblastoma

CG Brahm, UK Abdul, M Houweling… - Neuro-oncology …, 2020 - academic.oup.com
Background Patients with glioblastoma (GBM) have a dismal prognosis, and there is an
unmet need for new therapeutic options. This study aims to identify new therapeutic targets …

Proteomic Landscape of Primary and Metastatic Brain Tumors for Heterogeneity Discovery

X Liu, S Yang, C Zhou, L Zhang, Y Xiong… - Available at SSRN … - papers.ssrn.com
Brain tumors, whether primary or secondary, have limited information about proteomic
changes despite advances in understanding the driver gene mutation and heterogeneity …

Metabolic modeling-based drug repurposing in Glioblastoma

C Tomi-Andrino, A Pandele, K Winzer, J King… - Scientific reports, 2022 - nature.com
The manifestation of intra-and inter-tumor heterogeneity hinders the development of
ubiquitous cancer treatments, thus requiring a tailored therapy for each cancer type …

Identification of a novel eighteen-gene signature of recurrent metastasis neuroblastoma

S Zhang, R Jiang, M Yang, T Wang, H Chen… - Journal of Molecular …, 2023 - Springer
Neuroblastoma is the most common malignant tumor in childhood, and metastases occur in
more than 30% patients. Recurrent metastasis is the main cause of poor prognosis and high …

Integrating Multi-Omics analysis for enhanced diagnosis and treatment of glioblastoma: A comprehensive Data-Driven approach

A Barzegar Behrooz, H Latifi-Navid, SC da Silva Rosa… - Cancers, 2023 - mdpi.com
Simple Summary The most prevalent and lethal primary brain tumor, glioblastoma
multiforme (GBM), exhibits fast growth and widespread invasion and has a poor prognosis …

Identification of novel therapeutic targets in glioblastoma with functional genomic mRNA profiling.

CG Brahm, AME Walenkamp, ME Van Linde… - 2017 - ascopubs.org
2018 Background: Glioblastoma (GBM), the most common primary brain tumor in adults,
universally recurs and has a dismal prognosis. Therefore, there is an unmet need for new …

Rembrandt: helping personalized medicine become a reality through integrative translational research

S Madhavan, JC Zenklusen, Y Kotliarov, H Sahni… - Molecular cancer …, 2009 - AACR
Finding better therapies for the treatment of brain tumors is hampered by the lack of
consistently obtained molecular data in a large sample set and the ability to integrate …

[HTML][HTML] Proteogenomic characterization and integrative analysis of glioblastoma multiforme

YC Song, GX Lu, HW Zhang, XM Zhong, XL Cong… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Glioblastoma multiforme (GBM), the most aggressive and lethal primary brain tumor, is
characterized by very low life expectancy. Understanding the genomic and proteogenomic …