A putative loop connection between VTA dopamine neurons and nucleus accumbens encodes positive valence to compensate for hunger

X Cui, Q Tong, H Xu, C Xie, L Xiao - Progress in Neurobiology, 2023 - Elsevier
Dopamine (DA) signal play pivotal roles in regulating motivated behaviors, including feeding
behavior, but the role of midbrain DA neurons in modulating food intake and neural circuitry …

A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation

Y Han, G Xia, Y He, Y He, M Farias, Y Xu, Q Wu - Science Advances, 2021 - science.org
The neural circuitry mechanism that underlies dopaminergic (DA) control of innate feeding
behavior is largely uncharacterized. Here, we identified a subpopulation of DA neurons …

[HTML][HTML] Anterior paraventricular thalamus to nucleus accumbens projection is involved in feeding behavior in a novel environment

J Cheng, J Wang, X Ma, R Ullah, Y Shen… - Frontiers in molecular …, 2018 - frontiersin.org
Foraging food in a novel environment is essential for survival. Animals coordinate the
complex motivated states and decide whether to initiate feeding or escape from unfamiliar …

A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice

X Cai, H Liu, B Feng, M Yu, Y He, H Liu, C Liang… - Nature …, 2022 - nature.com
Midbrain dopamine (DA) and serotonin (5-HT) neurons regulate motivated behaviors,
including feeding, but less is known about how these circuits may interact. In this study, we …

[PDF][PDF] Accumbal D1R neurons projecting to lateral hypothalamus authorize feeding

EC O'Connor, Y Kremer, S Lefort, M Harada, V Pascoli… - Neuron, 2015 - cell.com
Feeding satisfies metabolic need but is also controlled by external stimuli, like palatability or
predator threat. Nucleus accumbens shell (NAcSh) projections to the lateral hypothalamus …

Zona incerta dopamine neurons encode motivational vigor in food seeking

Q Ye, J Nunez, X Zhang - Science Advances, 2023 - science.org
Energy deprivation triggers food seeking to ensure homeostatic consumption, but the neural
coding of motivational vigor in food seeking during physical hunger remains unknown. Here …

Does activation of midbrain dopamine neurons promote or reduce feeding?

L Boekhoudt, TJM Roelofs, JW De Jong… - International Journal of …, 2017 - nature.com
Background: Dopamine (DA) signalling in the brain is necessary for feeding behaviour, and
alterations in the DA system have been linked to obesity. However, the precise role of DA in …

Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake

DM Mebel, JCY Wong, YJ Dong… - European Journal of …, 2012 - Wiley Online Library
Mesolimbic dopamine (DA) signaling has been implicated in the incentive, reinforcing and
motivational aspects of food intake. Insulin receptors are expressed on dopaminergic …

Lateral hypothalamic area neuropeptides modulate ventral tegmental area dopamine neurons and feeding

P Perez-Bonilla, K Santiago-Colon, GM Leinninger - Physiology & behavior, 2020 - Elsevier
Understanding how the brain coordinates energy status with the motivation to eat is crucial
to identify strategies to improve disordered body weight. The ventral tegmental area (VTA) …

[HTML][HTML] Overlapping representations of food and social stimuli in VTA dopamine neurons

L Willmore, AR Minerva, B Engelhard, M Murugan… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Dopamine neurons of the ventral tegmental area (VTA DA) respond to food and social
stimuli and contribute to both forms of motivation. However, it is unclear if the same or …