Nicotine and its derivatives, by binding to nicotinic acetylcholine receptors (nAChR) on
bronchial epithelial cells, can regulate cellular proliferation and apoptosis via activating the …

Nicotinic acetylcholine receptors (nAChR) are expressed on non-neuronal cell types,
including normal bronchial epithelial cells, and nicotine has been reported to cause Akt …

Retrospective studies have shown that patients with tobacco-related cancers who continue
to smoke after their diagnoses have lower response rates and shorter median survival …

Forty-eight million Americans smoke because of addiction to nicotine, and prevention of
smoking initiation and new methods for aiding in smoking cessation are some of the most …

Objectives: Lung cancer is the most common cause of cancer death in the world. Cigarette
smoking represents the major risk factor. Nicotine, an active component of cigarettes, can …

Despite the known adverse health effects associated with tobacco use, over 45 million
adults in the United States smoke. Cigarette smoking is the major etiologic factor associated …

By binding to nicotinic acetylcholine receptors (nAChRs), nicotine induces the proliferation
and apoptosis of non-small cell lung cancer (NSCLC). Previous studies have indicated that …

The genotoxic effects of tobacco carcinogens have long been recognized, the contribution of
tobacco components to cancerogenesis by cell surface receptor signaling is relatively …

The respiratory epithelium expresses the cholinergic system including nicotinic receptors
(nAChRs). It was reported that normal human bronchial epithelial cells (BEC), which are the …

Background and Purpose Tobacco smoke contains many classes of carcinogens and
although nicotine is unable to initiate tumourigenesis in humans and rodents, it promotes …