TIMP3/Wnt axis regulates gliosis of Müller glia
JH Hung, PH Tsai, FA Wilson Jr, CC Chen… - … et Biophysica Acta (BBA …, 2024 - Elsevier
Background Previous studies have confirmed the expression of tissue inhibitor of
metalloproteinase-3 (TIMP3) in Müller glia (MG). However, the role of TIMP3 in MG remains …
metalloproteinase-3 (TIMP3) in Müller glia (MG). However, the role of TIMP3 in MG remains …
[HTML][HTML] Matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinases 1 (TIMP-1) are localized in the nucleus of retinal Müller glial cells and …
EJ Lee, M Zheng, CM Craft, S Jeong - Plos one, 2021 - journals.plos.org
Matrix metalloproteinases (MMPs) are involved in the pathology of numerous inflammatory
retinal degenerations, including retinitis pigmentosa (RP). Our previous work revealed that …
retinal degenerations, including retinitis pigmentosa (RP). Our previous work revealed that …
[HTML][HTML] The TGFβ/Notch axis facilitates Müller cell-to-epithelial transition to ultimately form a chronic glial scar
FM Conedera, AMQ Pousa, N Mercader… - Molecular …, 2021 - Springer
Background Contrasting with zebrafish, retinal regeneration from Müller cells (MCs) is
largely limited in mammals, where they undergo reactive gliosis that consist of a …
largely limited in mammals, where they undergo reactive gliosis that consist of a …
[HTML][HTML] Abnormal vessel formation in the choroid of mice lacking tissue inhibitor of metalloprotease-3
A Janssen, J Hoellenriegel, M Fogarasi… - … & visual science, 2008 - arvojournals.org
purpose. Tissue inhibitor of metalloprotease (TIMP)-3 is an inhibitor of matrix
metalloprotease (MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated …
metalloprotease (MMP) and regulates angiogenesis. In the eye, TIMP3 is tightly associated …
[HTML][HTML] TIMP-3 in Bruch's membrane: changes during aging and in age-related macular degeneration
M Kamei, JG Hollyfield - Investigative ophthalmology & visual …, 1999 - iovs.arvojournals.org
purpose. To assess the distribution, content, and function of tissue inhibitor of
metalloproteinases (TIMP)-3 during aging in normal eyes for comparison with the levels …
metalloproteinases (TIMP)-3 during aging in normal eyes for comparison with the levels …
[HTML][HTML] Tissue inhibitor of metalloproteinases 1 enhances rod survival in the rd1 mouse retina
HS Kim, A Vargas, YS Eom, J Li, KL Yamamoto… - PloS one, 2018 - journals.plos.org
Retinitis pigmentosa (RP), an inherited retinal degenerative disease, is characterized by a
progressive loss of rod photoreceptors followed by loss of cone photoreceptors. Previously …
progressive loss of rod photoreceptors followed by loss of cone photoreceptors. Previously …
[HTML][HTML] Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3
Q Ebrahem, JH Qi, M Sugimoto, M Ali… - … & visual science, 2011 - iovs.arvojournals.org
Purpose.: Tissue inhibitor of metalloproteinases-3 (TIMP-3) is a matrix-bound inhibitor of
matrix metalloproteinases (MMPs). The authors have previously determined a novel function …
matrix metalloproteinases (MMPs). The authors have previously determined a novel function …
[HTML][HTML] Wnt regulates proliferation and neurogenic potential of Müller glial cells via a Lin28/let-7 miRNA-dependent pathway in adult mammalian retinas
K Yao, S Qiu, L Tian, WD Snider, JG Flannery… - Cell reports, 2016 - cell.com
In cold-blooded vertebrates such as zebrafish, Müller glial cells (MGs) readily proliferate to
replenish lost retinal neurons. In mammals, however, MGs lack regenerative capability as …
replenish lost retinal neurons. In mammals, however, MGs lack regenerative capability as …
GMFB/AKT/TGF‐β3 in Müller cells mediated early retinal degeneration in a streptozotocin‐induced rat diabetes model
T Zhu, Y Li, L Zhu, J Xu, Z Feng, H Chen, S Shi, C Liu… - Glia, 2024 - Wiley Online Library
Retinal degeneration, characterized by Müller cell gliosis and photoreceptor apoptosis, is
considered an early event in diabetic retinopathy (DR). Our previous study proposed that …
considered an early event in diabetic retinopathy (DR). Our previous study proposed that …
[HTML][HTML] Matrix metalloproteinases in the mouse retina: a comparative study of expression patterns and MMP antibodies
L De Groef, L Andries, K Lemmens, I Van Hove… - BMC …, 2015 - Springer
Abstract Background Matrix metalloproteinases (MMPs), a family of Zn 2+-dependent
endoproteases, have been shown to act as fine regulators of both health and disease …
endoproteases, have been shown to act as fine regulators of both health and disease …