Circadian rhythms are essential to physiological homeostasis, but often disrupted in the
intensive care unit (ICU) due to the absence of natural zeitgebers and exposure to …

Circadian rhythms are an integral part of life on earth. Circadian rhythms play a fundamental
role in homeostasis as they ensure coordination between the environment and an …

Objectives: Circadian rhythms are severely disrupted among the critically ill. These circadian
arrhythmias impair mentation, immunity, autonomic function, endocrine activity, hormonal …

Circadian rhythms play a vital role in metabolic, hormonal, and immunologic function and
are often disrupted in patients in the ICU. Circadian rhythms modulate the molecular …

Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …

Intensive care unit patients typically exhibit pathologic wakefulness, poor quality of daytime
sleep, nocturnal sleep fragmentation, and sleep patterns that feature the absence of slow …

Many physiological and cellular processes cycle with time, with the period between one
peak and the next being roughly equal to 24 h. These circadian rhythms underlie 'permissive …

Objective: Circadian rhythms are intrinsic timekeeping mechanisms that allow for adaptation
to cyclic environmental changes. Increasing evidence suggests that circadian rhythms may …

A fundamental aspect of human physiology is its cyclical nature over a 24-h period, a feature
conserved across most life on Earth. Organisms compartmentalise processes with respect to …

Two Billion Years ago all organisms had to adapt to two major changes: Sunlight and
oxygen. Based on these significant changes, all organisms and finally the human body …