Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function
Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
The Tabula Sapiens Consortium*, RC Jones… - Science, 2022 - science.org
Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs …
revolutionizing cell biology and enabling new insights into the physiology of human organs …
Mapping cell types across human tissues
Z Liu, Z Zhang - Science, 2022 - science.org
Our understanding of how cells form distinct tissues and organs and interact with each other
is limited. Recent single-cell RNA sequencing (scRNA-seq) analyses have described the …
is limited. Recent single-cell RNA sequencing (scRNA-seq) analyses have described the …
Understanding multicellular function and disease with human tissue-specific networks
Tissue and cell-type identity lie at the core of human physiology and disease. Understanding
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
the genetic underpinnings of complex tissues and individual cell lineages is crucial for …
Interpreting non-coding disease-associated human variants using single-cell epigenomics
Genome-wide association studies (GWAS) have linked hundreds of thousands of sequence
variants in the human genome to common traits and diseases. However, translating this …
variants in the human genome to common traits and diseases. However, translating this …
Complementing tissue characterization by integrating transcriptome profiling from the Human Protein Atlas and from the FANTOM5 consortium
Understanding the normal state of human tissue transcriptome profiles is essential for
recognizing tissue disease states and identifying disease markers. Recently, the Human …
recognizing tissue disease states and identifying disease markers. Recently, the Human …
Mapping human cell phenotypes to genotypes with single-cell genomics
JG Camp, R Platt, B Treutlein - Science, 2019 - science.org
The cumulative activity of all of the body's cells, with their myriad interactions, life histories,
and environmental experiences, gives rise to a condition that is distinctly human and specific …
and environmental experiences, gives rise to a condition that is distinctly human and specific …
Identifying disease-critical cell types and cellular processes by integrating single-cell RNA-sequencing and human genetics
Genome-wide association studies provide a powerful means of identifying loci and genes
contributing to disease, but in many cases, the related cell types/states through which genes …
contributing to disease, but in many cases, the related cell types/states through which genes …
A reference single-cell transcriptomic atlas of human skeletal muscle tissue reveals bifurcated muscle stem cell populations
Single-cell RNA-sequencing (scRNA-seq) facilitates the unbiased reconstruction of
multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq …
multicellular tissue systems in health and disease. Here, we present a curated scRNA-seq …
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Detailed characterization of the cell types in the human brain requires scalable experimental
approaches to examine multiple aspects of the molecular state of individual cells, as well as …
approaches to examine multiple aspects of the molecular state of individual cells, as well as …