BACKGROUND Prostate carcinoma (PC) frequently metastasizes to bone, where it causes
significant morbidity and mortality. Stromal elements in the primary and metastatic target …

Prostate cancer (PCa) epithelial cells require a number of factors to facilitate their
establishment and growth at a distant site of metastasis. Their ability to adapt to their …

It is becoming increasingly clear that a prostate cancer cell's microenvironment is crucial to
its survival, progression, and metastasis. However, the mechanisms by which the tumor cell …

BACKGROUND The homing of prostate carcinoma to bone is a nonrandom, multistep
process. Previous studies have revealed significant insights into how tumor cells can interact …

Prostate cancer selectively metastasizes to the axial skeleton to produce osteoblastic
lesions, which suggests that bidirectional paracrine interactions exist between prostate …

Prostate carcinoma (PRCA) cells metastasize to the skeleton with high frequency. Bone
stores growth regulatory factors, which are released in active form during bone remodeling …

Cancer is not a single-cell disease, and its existence and behavior are constantly modulated
by the host. Cancer gene expression and genetics are also highly dynamic and are …

PURPOSE: Tumor cell genotype and phenotype have been considered the only
determinants supporting cancer growth and metastasis. This review focuses on the …

Bone remains one of the major sites, and most lethal host organs, for prostate cancer
metastasis. Prostate cell spread and establishment in bone depends on multiple reciprocal …

Prostate cancers (PRCAs) frequently metastasize to bone. We show here that this process is
facilitated by osteoblast‐mediated tumor cell recruitment. Transforming growth factor‐β1 …