▪ Abstract While still incomplete, the first data concerning the biochemistry of T cell receptor–
ligand interactions in cell-free systems seem to have considerable predictive value …

T-cell activation occurs when the T-cell receptor (TCR) binds to a self major
histocompatibility complex JMHC) molecule carrying a specific peptide. Small changes in …

Recent results have added new information to our understanding of a~ 8 T-cell receptor
mediated recognition. In particular, we find that the V (D) J junction or'CDR3'portion of TCRa …

▪ Abstract Exciting breakthroughs in the last two years have begun to elucidate the structural
basis of cellular immune recognition. Crystal structures have been determined for full-length …

Cell surface‐expressed receptors are often multichain complexes. One of these, the T cell
receptor (TcR) αβ‐CD3 complex, is known to contain at least seven chains: the α and β TcR …

Whether there is one or multiple αβT cell antigen receptor (TCR) recognition modules in a
given TCR/CD3 complex is a long-standing controversy in immunology. We show that T …

▪ Abstract Over the past decade, key protein interactions contributing to T cell antigen
recognition have been characterized in molecular detail. These have included interactions …

Selective pairwise interactions between CD3 chains and the clonotypic T cell antigen
receptor (TCR)‐α,‐β chains has recently been established. In this study, the region of …

A large body of information about antigen receptors on the surface of T lymphocytes has
been gathered in the last five years (1, 2). T cell receptors use a variable region gene pool …

A defining characteristic of the vertebrate adaptive immune system is its specificity, which
arises from clonally distributed receptors encoded by gene segments that undergo somatic …