Abstract Treatment of cancer metastasis has been largely ineffective. It is paramount to
understand the mechanisms underlying the metastatic process, of which the tumor …

It has been increasingly recognized that tumor microenvironment plays an important role in
carcinogenesis. Inflammatory component is present and contributes to tumor proliferation …

The fatality of cancer predominantly results from the dissemination of primary tumor cells to
distant sites and the subsequent formation of metastases. During tumor progression, some …

Metastatic disease is the major challenge of cancer that accounts for over 90% of total
cancer lethality. Mounting clinical and preclinical data now indicate that inflammation, a …

Simple Summary Metastasis, the process by which cancer cells escape primary tumor site
and colonize distant organs, is responsible for most cancer-related deaths. The tumor …

Metastatic progression combined with non-responsiveness towards systemic therapy often
shapes the course of disease for cancer patients and commonly determines its lethal …

Cancer metastasis is responsible for the vast majority of cancer‐related deaths worldwide. In
contrast to numerous discoveries that reveal the detailed mechanisms leading to the …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

The dynamic interplay between neoplastic cells and the immune microenvironment
regulates every step of the metastatic process. Immune cells contribute to invasion by …

Metastatic disease is the primary cause of death for most cancer patients. Complex and
redundant pathways involving the tumor cell and the microenvironment mediate tumor …