ATP-binding cassette (ABC) transporters are integral membrane proteins that translocate a
wide variety of substrates across cellular membranes and are conserved from bacteria to …

Driven by the energy of ATP binding and hydrolysis, ATP-binding cassette transporters
alternate between inward-and outward-facing conformations, allowing vectorial movement …

ATP-binding cassette (ABC) exporters use the energy of ATP hydrolysis to transport
substrates across membranes. ABC proteins contain two transmembrane domains that form …

MsbA is an ATP-binding cassette transporter from Escherichia coli that is involved in
trafficking lipid A across the inner membrane. ATP-binding cassette transporters harness the …

Multidrug resistance (MDR) is a serious medical problem and presents a major challenge to
the treatment of disease and the development of novel therapeutics. ABC transporters that …

Studies of periplasmic binding protein-dependent transporters date to the 1960s when it was
realized that the transport of certain solutes was inhibited following an osmotic shock that …

ABC (ATP-binding cassette) transporters are primary active membrane proteins that
translocate solutes (allocrites) across lipid bilayers. The prototypical ABC transporter …

All living organisms depend on primary and secondary membrane transport for the supply of
external nutrients and removal or sequestration of unwanted (toxic) compounds. Due to the …

ATP-binding cassette (ABC) transporters utilize the energy from ATP hydrolysis to transport
substances across the membrane. In recent years, crystal structures of several ABC …

Members of the ATP-binding cassette (ABC) superfamily are integral membrane proteins
that hydrolyze ATP to drive transport. In the last two decades these proteins have been …