Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects
KA Sheikh, J Sun, Y Liu, H Kawai… - Proceedings of the …, 1999 - National Acad Sciences
Gangliosides are a family of sialic acid-containing glycosphingolipids highly enriched in the
mammalian nervous system. Although they are the major sialoglycoconjugates in the brain …
mammalian nervous system. Although they are the major sialoglycoconjugates in the brain …
Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon–glial interactions
T Yamashita, YP Wu, R Sandhoff… - Proceedings of the …, 2005 - National Acad Sciences
Gangliosides, which are sialylated glycosphingolipids, are the major class of
glycoconjugates on neurons and carry the majority of the sialic acid within the central …
glycoconjugates on neurons and carry the majority of the sialic acid within the central …
Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.
K Takamiya, A Yamamoto… - Proceedings of the …, 1996 - National Acad Sciences
Gangliosides, sialic acid-containing glycosphingolipids, are abundant in the vertebrate
(mammalian) nervous system. Their composition is spatially and developmentally regulated …
(mammalian) nervous system. Their composition is spatially and developmentally regulated …
[HTML][HTML] Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures
H Kawai, ML Allende, R Wada, M Kono… - Journal of Biological …, 2001 - ASBMB
Gangliosides are a family of glycosphingolipids that contain sialic acid. Although they are
abundant on neuronal cell membranes, their precise functions and importance in the central …
abundant on neuronal cell membranes, their precise functions and importance in the central …
High‐affinity anti‐ganglioside IgG antibodies raised in complex ganglioside knockout mice: reexamination of GD1a immunolocalization
MPT Lunn, LAA Johnson, SE Fromholt… - Journal of …, 2000 - Wiley Online Library
Gangliosides, sialic acid‐bearing glycosphingolipids, are highly enriched in the vertebrate
nervous system. Anti‐ganglioside antibodies are associated with various human …
nervous system. Anti‐ganglioside antibodies are associated with various human …
[HTML][HTML] Brain gangliosides in axon–myelin stability and axon regeneration
RL Schnaar - FEBS letters, 2010 - Elsevier
Gangliosides, sialic acid-bearing glycosphingolipids, are expressed at high abundance and
complexity in the brain. Altered ganglioside expression results in neural disorders, including …
complexity in the brain. Altered ganglioside expression results in neural disorders, including …
[HTML][HTML] Differential distribution of major brain gangliosides in the adult mouse central nervous system
Gangliosides-sialic acid-bearing glycolipids-are major cell surface determinants on neurons
and axons. The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise …
and axons. The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise …
Gangliosides of the vertebrate nervous system
RL Schnaar - Journal of molecular biology, 2016 - Elsevier
Gangliosides, sialylated glycosphingolipids, found on all vertebrate cells and tissues, are
major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a …
major molecular determinants on the surfaces of vertebrate nerve cells. Composed of a …
Biosynthesis of the major brain gangliosides GD1a and GT1b
ER Sturgill, K Aoki, PHH Lopez, D Colacurcio… - …, 2012 - academic.oup.com
Gangliosides—sialylated glycosphingolipids—are the major glycoconjugates of nerve cells.
The same four structures—GM1, GD1a, GD1b and GT1b—comprise the great majority of …
The same four structures—GM1, GD1a, GD1b and GT1b—comprise the great majority of …
[HTML][HTML] Sialylation regulates brain structure and function
Every cell expresses a molecularly diverse surface glycan coat (glycocalyx) comprising its
interface with its cellular environment. In vertebrates, the terminal sugars of the glycocalyx …
interface with its cellular environment. In vertebrates, the terminal sugars of the glycocalyx …