Tissue engineering is an emerging multidisciplinary field of investigation focused on the
regeneration of diseased or injured tissues through the delivery of appropriate molecular …

Bone loss and failure of proper bone healing continues to be a significant medical condition
in need of solutions that can be implemented successfully both in human and veterinary …

Although bone has a high potential to regenerate itself after damage and injury, the
efficacious repair of large bone defects resulting from resection, trauma or non-union …

With an increasing life expectancy and aging population, orthopedic defects and bone graft
surgeries are increasing in global prevalence. Research to date has advanced the …

Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or
selective surgery have in many cases presented insurmountable challenges to the current …

Highlights•Clinically inspired performance criteria for designing holistic tissue regenerative
therapeutics.•Recent advances in the design of therapeutics using stem cells, growth factors …

Novel tissue regeneration strategies are constantly being developed worldwide. Research
on bone regeneration is noteworthy, as many promising new approaches have been …

Bone fracture followed by delayed or non-union typically requires bone graft intervention.
Autologous bone grafts remain the clinical “gold standard”. Recently, synthetic bone grafts …

Bone is a dynamic tissue that undergoes significant turnover during the life cycle of an
individual. Despite having a significant regenerative capability, trauma and other …

A significant challenge in the current orthopedics is the development of suitable
osteobiologic materials that can replace the conventional allografts, autografts, and …