Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that
forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor neurons in …

Mutations in TDP-43 cause amyotrophic lateral sclerosis (ALS), a fatal paralytic disease
characterized by degeneration and premature death of motor neurons. The contribution of …

Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …

Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease that causes motor neuron
degeneration, progressive motor dysfunction, paralysis, and death. Although multiple …

Accumulations of aggregated proteins are a key feature of the pathology of all of the major
neurodegenerative diseases. Amyotrophic lateral sclerosis (ALS) was brought into this fold …

Amyotrophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease
caused by motor neuron loss, resulting in muscle wasting, paralysis and eventual death. A …

Abstract Phosphorylated TDP-43 (pTDP-43) aggregates in the cytoplasm of motor neurons
and neuroglia in the brain are one of the pathological hallmarks of amyotrophic lateral …

Despite the strong evidence linking the transactive response DNA-binding protein 43 (TDP-
43) aggregation to the pathogenesis of frontotemporal lobar degeneration with TDP-43 …

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …

Transactive response DNA-binding protein-43 (TDP-43) is a multifunctional nucleic acid
binding protein present in ubiquitinated inclusions in tissues of patients with amyotrophic …