A major cause of cancer recurrence following chemotherapy is cancer dormancy escape.
Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing …

Patients with breast cancer often develop malignant regrowth of residual drug-resistant
dormant tumor cells years after primary treatment, a process defined as cancer relapse …

Background The ability of a tumor to become dormant in response to suboptimal conditions
has recently been recognized as a key step in tumor progression. Tumor dormancy has …

Breast cancer stem cells (BCSCs) play a critical role in tumor recurrence and metastasis.
Exposure of breast cancer cells to chemotherapy leads to an enrichment of BCSCs. Here …

Tumor stroma is a major contributor to the biological aggressiveness of cancer cells. Cancer
cells induce activation of normal fibroblasts to carcinoma-associated fibroblasts (CAFs) …

Background/Aim: One of the major hurdles in the treatment of breast cancers is the inability
of anti-cancer drugs to eliminate the breast cancer stem cells (BCSCs) population, which …

Breast cancer (BC) can recur as metastatic disease many years after primary tumor removal,
suggesting that disseminated tumor cells survive for extended periods in a dormant state …

Distant relapse after chemotherapy is an important clinical issue for treating breast cancer
patients and results from the development of cancer stem-like cells (CSCs) during …

Background Chemotherapy remains a standard treatment option for breast cancer despite
its toxic effects to normal tissues. However, the long-lasting effects of chemotherapy on non …

Cancer stem cells (CSCs) are a minority subset of cancer cells that can drive tumor initiation,
promote tumor progression, and induce drug resistance. CSCs are difficult to eliminate by …