Transplantation (CIT) Consortium jointly developed and implemented a harmonized process
for manufacture of the allogeneic Purified Human Pancreatic Islet (PHPI) product evaluated …

Eight manufacturing facilities participating in the National Institutes of Health–sponsored
Clinical Islet Transplantation (CIT) Consortium jointly developed and implemented a …

Background. Difficulties with recovering and preserving pancreatic islets have hampered
progress in islet transplantation. In previous in vitro studies, our laboratory successfully …

The relative inefficiency of the islet purification process may hamper obtaining enough islets
for transplantation even with adequate pre-purification counts. In this study, we determined …

Hypothesis A local multiorgan donor pancreas procurement program can provide a source
for optimized isolation of purified viable islets for transplantation into patients with type 1 …

Human islet research is crucial to understanding the cellular biology of the pancreas in
developing therapeutic options for diabetes patients and in attempting to prevent the …

Postisolation islet survival is a critical step for achieving successful and efficient islet
transplantation. This involves the optimization of islet culture in order to prolong survival and …

Pancreatic islet transplantation is a promising treatment for diabetes but still faces several
challenges. Poor islet isolation efficiency and poor long-term insulin independence are …

The limited availability of human donors makes the search for alternative islet sources
mandatory for future developments in pancreatic islet transplantation. In this study, we report …

Background. As a result of advances in both immunosuppressive protocols and pancreatic
islet isolation techniques, insulin independence has recently been achieved in several …