Background MYCN-amplified RB1 wild-type (MYCN A RB1+/+) retinoblastoma is a rare but
clinically important subtype of retinoblastoma due to its aggressive character and relative …

Purpose Retinoblastomas are malignant eye tumors diagnosed in young children. Most
retinoblastomas are genetically characterized by biallelic inactivation of the RB1 gene …

Background Retinoblastoma is a pediatric eye cancer associated with RB1 loss or MYCN
amplification (RB1+/+ MYCN A). There are controversies concerning the existence of …

Retinoblastoma is a childhood eye malignancy that can lead to the loss of vision, eye (s),
and sometimes life. The tumors are initiated by inactivating mutations in both alleles of the …

Chromosomal abnormalities that involve the MYCN gene are rare; however, it is one of the
most commonly mutated genes in retinoblastoma (RB) after the RB1 gene. MYCN is …

Background: Absence of RB1 mutation is rare in retinoblastoma and MYCN amplifications
were recently identified in a subset of aggressive retinoblastomas occurring in infants. Here …

ABSTRACT Background: Retinoblastoma (Rb) is a childhood tumor of the developing retina
where predisposition is caused by RB1 pathogenic variants. MYCN amplification (MYCNA) …

Background Retinoblastoma is the childhood retinal cancer that defined tumour-suppressor
genes. Previous work shows that mutation of both alleles of the RB1 retinoblastoma …

Retinoblastoma (RB) is an inherited retinal disorder (IRD) caused by the mutation in the RB1
gene or, rarely, by alterations in the MYCN gene. In recent years, new treatment advances …

The pediatric ocular cancer retinoblastoma is the only central nervous system (CNS) tumor
readily observed without specialized equipment: it can be seen by, and in, the naked eye …