Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma

C Huang, L Chen, SR Savage, RV Eguez, Y Dou, Y Li… - Cancer cell, 2021 - cell.com
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …

[HTML][HTML] The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies

D Martin, MC Abba, AA Molinolo, L Vitale-Cross… - Oncotarget, 2014 - ncbi.nlm.nih.gov
The recent elucidation of the genomic landscape of head and neck squamous cell
carcinoma (HNSCC) has provided a unique opportunity to develop selective cancer …

Pharmacogenomic landscape of head and neck squamous cell carcinoma informs precision oncology therapy

Z Gu, Y Yao, G Yang, G Zhu, Z Tian, R Wang… - Science translational …, 2022 - science.org
Head and neck squamous cell carcinoma (HNSCC) is a common and frequently lethal
cancer with few therapeutic options. In particular, there are few effective targeted therapies …

Genomic and transcriptomic characterization links cell lines with aggressive head and neck cancers

H Cheng, X Yang, H Si, AD Saleh, W Xiao, J Coupar… - Cell reports, 2018 - cell.com
Cell lines are important tools for biological and preclinical investigation, and establishing
their relationship to genomic alterations in tumors could accelerate functional and …

[HTML][HTML] Molecular landscape of head and neck cancer and implications for therapy

CS Farah - Annals of Translational Medicine, 2021 - ncbi.nlm.nih.gov
Head and neck squamous cell carcinomas (HNSCC) arising from the oral cavity, pharynx,
and larynx constitute the 6 th most common human cancer. Human papillomavirus (HPV) …

Genomic landscapes of EBV-associated nasopharyngeal carcinoma vs. HPV-associated head and neck cancer

HL Ngan, L Wang, KW Lo, VWY Lui - Cancers, 2018 - mdpi.com
Epstein-Barr virus-positive nasopharyngeal carcinoma (EBV (+) NPC), and human
papillomavirus-positive head and neck squamous cell carcinoma (HPV (+) HNSCC) are two …

Genomic insights into head and neck cancer

TN Beck, EA Golemis - Cancers of the head & neck, 2016 - Springer
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide and is frequently impervious to curative treatment efforts. Similar to other cancers …

Therapeutic insights from genomic studies of head and neck squamous cell carcinomas

PS Hammerman, DN Hayes, JR Grandis - Cancer discovery, 2015 - AACR
Large and comprehensive genomic surveys of head and neck squamous cell carcinomas
(HNSCC) are now greatly increasing our understanding of the diversity of this disease and …

Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

SV Puram, M Mints, A Pal, Z Qi, A Reeb, K Gelev… - Nature …, 2023 - nature.com
Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by
human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive …

Molecular profiling of head and neck squamous cell carcinoma

R Feldman, Z Gatalica, J Knezetic, S Reddy… - Head & …, 2016 - Wiley Online Library
Background Head and neck squamous cell carcinoma (HNSCC) exhibits high rates of
recurrence, and with few approved targeted agents, novel treatments are needed. We …