The T lineage glycoprotein CD6 is generally considered to be a costimulator of T‐cell
activation. Here, we demonstrate that CD6 significantly reduces early and late T‐cell …

The CD5 lymphocyte surface glycoprotein is a coreceptor involved in the modulation of
antigen-specific receptor-mediated activation and differentiation signals. Although first …

CD6 immunotherapy to treat psoriasis and rheumatoid arthritis has reached the clinical trial
stage with apparent success, and targeting CD6 with mAbs is being used in several animal …

Background CD6 is one of many cell surface receptors known to regulate signal
transduction upon T cell activation. However, whether CD6 mediates costimulatory or …

T cell activation is controlled by the coordination of stimulatory and negative regulatory
signals which are not completely defined. In this study we tested for a possible direct effect of …

CD2 is largely described to promote T cell activation when engaged by its ligands, CD48 in
mice and CD58 in humans, that are present on antigen-presenting cells (APCs). However …

T‐cell activation requires engagement of the T‐cell receptor and of at least one
costimulatory molecule. The key role of CD28 in inducing T‐cell activation was reported …

CD6 is a cell surface receptor expressed on immature thymocytes and mature T and B1a
lymphocytes. The ultimate function of CD6 has not been deciphered yet, but much evidence …

Functions of the CD8 molecule were examined to determine whether CD8 is merely a ligand-
binding molecule and/or is involved in signal transduction. Using KT112 (anti-CD8β), CD8 …

CD5 is a lymphoid-specific transmembrane glycoprotein constitutively expressed on
thymocytes and mature T and B1a lymphocytes. Current data support the view that CD5 is a …