p38 mitogen-activated protein (MAP) kinases are the serine/threonine protein kinases,
which play a vital role in cellular responses to external stress signals. p38 MAP kinase …

A novel structural class of p38α MAP kinase inhibitors has been identified via iterative SAR
studies of a focused deck screen hit. Optimization of the lead series generated 6e, BMS …

Inflammation is a complex immune response to cellular and tissue damage caused by
physical, chemical, immunological, or microbial stimuli [1]. Prior to the successful launch of …

Background: The inflammatory process is one of the mechanisms by which our body
upholds us from pathogens such as parasites, bacteria, viruses, and other harmful …

Mitogen-activated protein kinases (MAPKs) are a group of serine-threonine protein kinases
that can be activated by extracellular stimuli. MAPK14 (p38α) affects major disease …

The p38 mitogen-activated protein (MAP) kinase plays a central role in inflammation. It has
been the subject of extensive efforts in both basic research and drug discovery for the …

p38 Mitogen-activated protein kinase (MAPK) has been considered to be a promising target
for the development of therapeutics for various immunologic diseases. Herein we report an …

p38 is a member of the mitogen-activated protein (MAP) kinase family and is a critical
enzyme in the proinflammatory cytokine pathway. Other MAP kinase group members that …

A novel series of N-pyridyl amides as potent p38α kinase inhibitors is described. Based on
the structural similarities between the initial hit and a well-known imidazole pyrimidine series …

P38 mitogen-activated protein (MAP) kinase inhibitors are closely involved in the production
of inflammatory cytokines. These compounds are considered promising therapeutic agents …