The recent development of high throughput compound screening has allowed drug
repurposing to emerge as an effective avenue for discovering novel treatments for cancer …

Cancer is a major public health problem and one of the leading contributors to the global
disease burden. The high cost of development of new drugs and the increasingly severe …

Cancer is a leading cause of death worldwide, with approximately 19 million new cases
each year. Lately, several novel chemotherapeutic drugs have been introduced, efficiently …

Phenothiazines (PTZs) have been used for the antipsychotic drugs for centuries. However,
some of these PTZs have been reported to exhibit antitumor effects by targeting various …

Epidemiological observations have shown that schizophrenia patients after long-term drug
treatment exhibited reduced tumor incidences. The potential anticancer effects of …

Pimozide is currently being used in clinic as a neuroleptic and exerts versatile biological
actions. Pimozide is a cationic amphiphilic drug (CAD); CADs block the synthesis of neutral …

Despite decades of research and major efforts, malignant brain tumors remain among the
deadliest of all cancers. Recently, an increasing number of psychiatric drugs has been …

Over a century ago, the phenothiazine dye, methylene blue, was discovered to have both
antipsychotic and anti-cancer effects. In the 20th-century, the first phenothiazine …

Glioblastoma remains the most malignant of all primary adult brain tumours with poor patient
survival and limited treatment options. This study adopts a drug repurposing approach by …

Background and Purpose: Drug repositioning is a promising strategy for discovering new
therapeutic strategies for cancer therapy. We investigated psychotropic drugs for their …