Inflammation is at the forefront of carcinogenesis, tumor progression and resistance to
therapy. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) …

Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates
almost all immune regulatory processes, including those that are involved in tumor cell …

Cytokines are molecules that play critical roles in the regulation of a wide range of normal
functions leading to cellular proliferation, differentiation and survival, as well as in …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

JAK-STAT signalling is a cornerstone to cancer progression, either as a tumour intrinsic
driver of cancer growth/metastasis, or as a modulator of immune surveillance. This Special …

JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the
myriad of cellular processes initiated by various types of ligands such as growth factors …

Over the past decade, there has been increasing biochemical evidence that the Janus
kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is aberrantly …

Various human malignancies are characterized by excessive activation of the Janus family
of cytoplasmic tyrosine kinases (JAK) and their associated transcription factors STAT3 and …

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway,
essential for cellular communication, orchestrates a myriad of physiological and pathological …

The JAK-STAT pathway plays a central role in cell proliferation, differentiation, survival, and
embryological processes. Aberrant activation of the JAK-STAT pathway due to genetic …