The conserved acetyltransferase Gcn5 is a member of several complexes in eukaryotic cells,
playing roles in regulating chromatin organization, gene expression, metabolism, and cell …

The concept of chromatin as a regulator of gene expression has been the foundation for
nearly all studies of eukaryotic transcription over the past 25 years since the discovery of the …

Establishing causative links between protein functional domains and global gene regulation
is critical for advancements in genetics, biotechnology, disease treatment, and systems …

Histone acetyltransferases are key chromatin regulators responsible for transcriptional
activation and cell cycle progression. We propose a simple yeast-based assay to determine …

Distinct posttranslational modifications on histones occur in specific patterns to mediate
certain chromosomal events. For example, on histone H3, phosphorylation at Ser10 can …

The Saccharomyces cerevisiae transcription factor Gcn4 is expressed during amino acid
starvation, and its abundance is controlled by ubiquitin-mediated proteolysis. Cdk8, a kinase …

General control nonderepressible 5 protein (Gcn5) and its homologs, including p300/CBP-
associated factor (PCAF), are lysine acetyltransferases that modify both histone and non …

The Gcn5 histone acetyltransferase (HAT) is part of a large multimeric complex that is
required for transcriptional activation in yeast. This complex can acetylate in vitroand in a …

Histone acetyltransferases (HATs) are involved in the acetylation of core histones, which is
an important event for transcription regulation through alterations in the chromatin structure …

Histone acetyltransferases play important roles in the regulation of chromatin structure and
gene transcription. As one of the most important histone acetyltransferases, general control …