Age‐related declines in skeletal muscle regeneration have been attributed to muscle stem
cell (MuSC) dysfunction. Aged MuSCs display a fibrogenic conversion, leading to fibrosis …

During aging, the regenerative capacity of skeletal muscle decreases due to intrinsic
changes in muscle stem cells (MuSCs) and alterations in their niche. Here, we use …

Muscle stem cells (MuSCs) exhibit distinct behavior during successive phases of
developmental myogenesis. However, how their transition to adulthood is regulated is …

Background Skeletal muscle aging is associated with a decreased regenerative potential
due to the loss of function of endogenous stem cells or myogenic progenitor cells (MPCs) …

Skeletal muscle requires a highly orchestrated coordination between multiple cell types and
their microenvironment to exert its function and to maintain its homeostasis and regenerative …

The extracellular matrix (ECM) is an interconnected macromolecular scaffold occupying the
space between cells. Amongst other functions, the ECM provides structural support to …

The clonal complexity of adult stem cell pools is progressively lost during homeostatic
turnover in several tissues, suggesting a decrease in the number of stem cells with distinct …

Skeletal muscle regeneration is a coordinate process in which several factors are
sequentially activated to maintain and preserve muscle structure and function. The major …

The skeletal muscle microenvironment transiently remodels and stiffens after exercise and
injury, as muscle ages, and in myopathic muscle; however, how these changes in stiffness …

Adaptation to mechanical load, leading to enhanced force and power output, is a
characteristic feature of skeletal muscle. Formation of new myonuclei required for efficient …