Summary T cell factor 1 (TCF-1) is a transcription factor known to act downstream of the
canonical Wnt pathway and is essential for normal T cell development. However, its …

Immune protection from intracellular pathogens depends on the generation of terminally
differentiated effector and of multipotent memory precursor CD8 T cells, which rapidly …

Abstract T cell factor-1 (TCF-1) and lymphoid enhancer-binding factor 1, the effector
transcription factors of the canonical Wnt pathway, are known to be critical for normal …

The formation of central CD8 T cell memory in response to infection depends on the
transcription factor Tcf1 (Tcf7). Tcf1 is expressed at high levels in naive CD8 T cells but …

The transcription factor T cell factor 1 (TCF1), a pioneer transcription factor as well as a
downstream effector of WNT/β-catenin signaling, is indispensable for T cell development in …

Abstract T cell factor (TCF)-1 and lymphoid enhancer-binding factor (LEF)-1 transcription
factors have redundant roles in promoting thymocyte maturation. TCF-1 has been recently …

Expression of the transcription factor T-cell factor 1 (TCF1) identifies antigen-experienced
murine CD8+ T cells that retain potential for lymphoid recirculation and the ability to self …

Summary T cell factor 1 (Tcf1) promotes the central memory CD8+ T (T CM) cell
differentiation and stemness in lymphoid tissues after systemic infections. It remains unclear …

The developmental origins of memory T cells remain incompletely understood. During the
expansion phase of acute viral infection, we identified a distinct subset of virus-specific …

Memory CD8+ T-cell development is defined by the expression of a specific set of memory
signature genes. Despite recent progress, many components of the transcriptional control of …