Dynamic measurement of airway surface liquid volume with an ex vivo trachea-chip

M Scott, L Lei, KC Bierstedt, PB McCray, Y Xie - Lab on a Chip, 2024 - pubs.rsc.org
The volume and composition of airway surface liquid (ASL) is regulated by liquid secretion
and absorption across airway epithelia, controlling the pH, solute concentration, and …

Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl channel function

Y Song, W Namkung, DW Nielson… - … of Physiology-Lung …, 2009 - journals.physiology.org
The airway surface liquid (ASL) is the thin fluid layer lining the airways whose depth may be
reduced in cystic fibrosis. Prior measurements of ASL depth have been made in airway …

Regulation of airway surface liquid volume and mucus transport by active ion transport

R Tarran - Proceedings of the American Thoracic Society, 2004 - atsjournals.org
Mucus clearance is an important component of the lung's innate defense against disease,
and the ability of the airways to clear mucus is strongly dependent on the volume of liquid on …

Automated acquisition and analysis of airway surface liquid height by confocal microscopy

HC Choi, CSK Kim, R Tarran - American Journal of …, 2015 - journals.physiology.org
The airway surface liquid (ASL) is a thin-liquid layer that lines the luminal side of airway
epithelia. ASL contains many molecules that are involved in primary innate defense in the …

Volume transport across tracheal and bronchial airway epithelia in a tubular culture system

BR Grubb, FR Schiretz… - American Journal of …, 1997 - journals.physiology.org
Airway epithelia are thought to play an important role in maintaining the depth (volume) and
composition of airway surface liquid (ASL). However, due to the difficulty in measuring …

Sodium and chloride concentrations, pH, and depth of airway surface liquid in distal airways

Y Song, J Thiagarajah, AS Verkman - The Journal of general physiology, 2003 - rupress.org
The composition and depth of the airway surface liquid (ASL) are key parameters in airway
physiology that are thought to be important in the pathophysiology of cystic fibrosis and other …

Thin-film measurements of airway surface liquid volume/composition and mucus transport rates in vitro

R Tarran, RC Boucher - Cystic fibrosis methods and protocols, 2002 - Springer
Airway surface liquid (ASL) has been reported to vary in height from 5 to 100 µm (1, 2),
which likely reflects both regional/species variation and differences in methodologies …

[HTML][HTML] The small airways accordion: concurrent or alternating fluid absorption and secretion?

HR de Jonge, DN Sheppard - The Journal of Physiology, 2012 - ncbi.nlm.nih.gov
Airway surface liquid (ASL) homeostasis, achieved by balancing transepithelial fluid
absorption and secretion, is essential for mucociliary clearance and to prevent inundation …

Regulation of airway surface liquid volume by human airway epithelia

R Boucher - Pfluegers Archiv, 2003 - Springer
Mucus clearance on airway surfaces is a primary form of pulmonary defense. The efficiency
of mucus clearance in large part depends on the volume of the airway surface liquid …

Airway surface liquid volume expansion induces rapid changes in amiloride‐sensitive Na+ transport across upper airway epithelium‐Implications concerning the …

F Azizi, A Arredouani, RM Mohammad - Physiological Reports, 2015 - Wiley Online Library
During airway inflammation, airway surface liquid volume (ASLV) expansion may result from
the movement of plasma proteins and excess liquid into the airway lumen due to …