Context Research involving persons with impaired decision-making capacity (such as
persons with Alzheimer disease [AD]) remains ethically challenging, especially when the …

Objectives Investigators generally address the ethical dilemma of patients' decisional
impairment in Alzheimer disease (AD) research by obtaining consent from alternative or …

Background Assessment of decision-making capacity is a common and important function of
psychiatric consultants. However, the sources of variability in evaluators' judgments have not …

Surrogate (proxy) decision makers must make research decisions for people with dementia
who lack decision-making capacity. Proxies' decision-making processes are minimally …

Objectives This study examined the decision-making process used by individuals asked to
participate in dementia research and their opinions on how future proxy research decisions …

Objectives: To evaluate public opinion about participation in Alzheimer disease (AD)
research and willingness to have a proxy-informed consent. Design: Cross-sectional …

Objectives To explore the neuropsychological correlates of the capacity to consent to
research and to appoint a research proxy among persons with Alzheimer disease. Design …

Objectives Ethical guidelines suggest that, when enrolling patients with dementia in
research, alterative decision makers (proxies) should base their decision on a “substituted …

ABSTRACT Objective: Investigators conducting Alzheimer's disease (AD) research need to
consider participants' capacity to consent. Cognitive functioning is a significant predictor of …

Background: Research involving decisionally incapable adults remains an unsettled and
controversial policy issue, especially for protocols that involve significant risk to participants …