The role of cyclooxygenase‐2 in cell proliferation and cell death in human malignancies
It is well admitted that the link between chronic inflammation and cancer involves cytokines
and mediators of inflammatory pathways, which act during the different steps of …
and mediators of inflammatory pathways, which act during the different steps of …
Many actions of cyclooxygenase‐2 in cellular dynamics and in cancer
Y Cao, SM Prescott - Journal of cellular physiology, 2002 - Wiley Online Library
Abstract Cyclooxygenase‐2 (COX‐2) is the inducible isoform of cyclooxygenase, the
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …
enzyme that catalyzes the rate‐limiting step in prostaglandin synthesis from arachidonic …
Cyclooxygenase-1 (COX-1) and COX-1 inhibitors in cancer: A review of oncology and medicinal chemistry literature
A Pannunzio, M Coluccia - Pharmaceuticals, 2018 - mdpi.com
Prostaglandins and thromboxane are lipid signaling molecules deriving from arachidonic
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …
acid by the action of the cyclooxygenase isoenzymes COX-1 and COX-2. The role of …
Cyclooxygenase‐2 in cancer: a review
Abstract Cyclooxygenase‐2 (COX‐2) is frequently expressed in many types of cancers
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …
exerting a pleiotropic and multifaceted role in genesis or promotion of carcinogenesis and …
Cyclo-oxygenase-2 and its inhibition in cancer: is there a role?
Z Liao, KA Mason, L Milas - Drugs, 2007 - Springer
Despite recent improvements in chemotherapy and radiation therapy in cancer management
with the addition of biological agents, novel treatment approaches are needed to further …
with the addition of biological agents, novel treatment approaches are needed to further …
Cyclooxygenase-2: a novel target for cancer chemotherapy?
W Dempke, C Rie, A Grothey, HJ Schmoll - Journal of cancer research and …, 2001 - Springer
Epidemiologic studies have documented a 40–50% reduction in incidence of colorectal
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …
cancer in individuals taking nonsteroidal antiinflammatory drugs (NSAIDs). Since NSAIDs …
Biology of Cox-2: an application in cancer therapeutics
Z Khan, N Khan, RP Tiwari, NK Sah… - Current drug …, 2011 - ingentaconnect.com
Cyclooxygenase-2 (Cox-2) is an inducible enzyme involved in the conversion of arachidonic
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …
acid to prostaglandin and other eicosanoids. Molecular pathology studies have revealed …
Cyclooxygenase-2 upregulation as a perigenetic change in carcinogenesis.
S Tsuji, M Tsujii, S Kawano, M Hori - Journal of experimental & …, 2001 - europepmc.org
The present paper reviews current concepts on the role of cyclooxygenase (COX) in the
development of malignant tumors. An inducible isoform of cyclooxygenase is expressed in …
development of malignant tumors. An inducible isoform of cyclooxygenase is expressed in …
Cyclooxygenase-2 in oncogenesis
MT Rizzo - Clinica chimica acta, 2011 - Elsevier
Compelling experimental and clinical evidence supports the notion that cyclooxygenase-2,
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …
the inducible isoform of cyclooxygenase, plays a crucial role in oncogenesis. Clinical and …
Molecular pathology of cyclooxygenase-2 in neoplasia
E Fosslien - Annals of Clinical & Laboratory Science, 2000 - Assoc Clin Scientists
Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues.
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and …
Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and …