Therapeutic application of small extracellular vesicles (sEVs): pharmaceutical and pharmacokinetic challenges

Y Takakura, A Matsumoto… - Biological and …, 2020 - jstage.jst.go.jp
Small extracellular vesicles (sEVs), including exosomes as typical example, are cell-derived
vesicles comprising lipid bilayer with a diameter approximately 100 nm. sEVs are …

Extracellular Vesicles in Therapeutics: A Comprehensive Review on Applications, Challenges, and Clinical Progress

J Goo, Y Lee, J Lee, IS Kim, C Jeong - Pharmaceutics, 2024 - mdpi.com
Small Extracellular Vesicles (sEVs) are typically 30–150 nm in diameter, produced inside
cells, and released into the extracellular space. These vesicles carry RNA, DNA, proteins …

Small extracellular vesicles as a new class of medicines

I Lee, Y Choi, DU Shin, M Kwon, S Kim, H Jung… - Pharmaceutics, 2023 - mdpi.com
Extracellular vesicles (EVs) are nanovesicles that are naturally released from cells in a lipid
bilayer-bound form. A subset population with a size of 200 nm, small EVs (sEVs), is enticing …

Small extracellular vesicles‐based cell‐free strategies for therapy

Y Guo, H Wang, L Huang, L Ou, J Zhu, S Liu, X Xu - MedComm, 2021 - Wiley Online Library
Small extracellular vesicles (sEVs) are extracellular nanovesicles that contain bioactive
proteins, lipids, RNA, and DNA. A variety of biological process is regulated with sEVs. sEVs …

[PDF][PDF] Biodistribution of therapeutic extracellular vesicles

D Gupta, OPB Wiklander, MJA Wood… - Extracell. Vesicles Circ …, 2023 - f.oaes.cc
The field of extracellular vesicles (EVs) has seen a tremendous paradigm shift in the past
two decades, from being regarded as cellular waste bags to being considered essential …

Recent advancement and technical challenges in developing small extracellular vesicles for cancer drug delivery

T Geng, P Pan, E Leung, Q Chen, L Chamley… - Pharmaceutical …, 2021 - Springer
Extracellular vesicles (EVs) are a heterogeneous population of lipid bilayer membrane-
enclosed vesicles and act like 'messages in a bottle'in cell-cell communication by …

Extracellular vesicles: a rising star for therapeutics and drug delivery

S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …

Strategic design of extracellular vesicle drug delivery systems

JPK Armstrong, MM Stevens - Advanced drug delivery reviews, 2018 - Elsevier
Abstract Extracellular vesicles (EVs), sub-micron vectors used in intercellular
communication, have demonstrated great promise as natural drug delivery systems. Recent …

Small extracellular vesicle loading systems in cancer therapy: Current status and the way forward

YF Zhang, JB Shi, C Li - Cytotherapy, 2019 - Elsevier
Systemic chemotherapy is a conventional and important strategy for inhibition of cancer
progression, but it is usually accompanied by various adverse effects. Targeting drug …

Extracellular vesicles: powerful candidates in nano-drug delivery systems

X Liu, Y Cao, S Wang, J Liu, H Hao - Drug Delivery and Translational …, 2024 - Springer
Extracellular vesicles (EVs), which are nanoparticles that are actively released by cells,
contain a variety of biologically active substances, serve as significant mediators of …