Although West Nile virus (WNV) and other arthropod-borne viruses are a major public health
problem, the mechanisms of antiviral immunity in mosquitoes are poorly understood. Dicer …

Despite their importance as vectors of human and livestock diseases, relatively little is
known about innate antiviral immune pathways in mosquitoes and other insects. Previous …

Virus transmission and spread by arthropods is a major economic and public health
concern. The ongoing dissemination of arthropod-borne viruses by blood-feeding insects is …

Vector-borne viruses are an important class of emerging and re-emerging pathogens; thus,
an improved understanding of the cellular factors that modulate infection in their respective …

Virus recognition and response by the innate immune system are critical components of host
defense against infection. Activation of cell-intrinsic immunity and optimal priming of …

Mosquito-borne diseases are associated with major global health burdens. Aedes spp. and
Culex spp. are primarily responsible for the transmission of the most medically important …

Rift Valley fever virus (RVFV) is a Phlebovirus (Bunyaviridae family) transmitted by
mosquitoes. It infects humans and ruminants, causing dramatic epidemics and epizootics in …

ABSTRACT RIG-I and MDA5, two related pathogen recognition receptors (PRRs), are
known to be required for sensing various RNA viruses. Here we investigated the roles that …

Here, we show that the major mosquito vector for dengue virus uses the JAK-STAT pathway
to control virus infection. Dengue virus infection in Aedes aegypti mosquitoes activates the …

The small interfering RNA (siRNA) pathway is a major antiviral response in mosquitoes;
however, another RNA interference pathway, the PIWI-interacting RNA (piRNA) pathway …