Hyaluronic acid: known for almost a century, but still in vogue

A Lierova, J Kasparova, A Filipova, J Cizkova… - Pharmaceutics, 2022 - mdpi.com
Hyaluronic acid (HA) has a special position among glycosaminoglycans. As a major
component of the extracellular matrix (ECM). This simple, unbranched polysaccharide is …

Hyaluronan: the Jekyll and Hyde molecule

JO Cantor, PP Nadkarni - Inflammation & Allergy-Drug Targets …, 2006 - ingentaconnect.com
Hyaluronan (HA) is a variable length, long-chain polysaccharide containing repeating
disaccharide units of glucuronic acid and n-acetylglucosamine. Long considered a relatively …

[HTML][HTML] Hyaluronic acid and its biomedical applications: A review

M Dovedytis, ZJ Liu, S Bartlett - Engineered Regeneration, 2020 - Elsevier
Hyaluronic acid is a naturally occurring biopolymer possessing numerous functions within
the body including wound repair, cell migration, and cell signaling. Due to its versatility …

[PDF][PDF] Hyaluronic acid in inflammation and tissue regeneration

M Litwiniuk, A Krejner, MS Speyrer, AR Gauto, T Grzela - Wounds, 2016 - researchgate.net
Hyaluronic acid (HA), the main component of extracellular matrix, is considered one of the
key players in the tissue regeneration process. It has been proven to modulate via specific …

Hyaluronic acid: perspectives in lung diseases

L Allegra, SD Patrona, G Petrigni - Heparin-A Century of Progress, 2012 - Springer
Hyaluronic acid (HA) is a non-sulphated glycosaminoglycan. It is a natural polymer
characterised by a coiled linear chain in particularly well-hydrated configuration composed …

Hyaluronic acid for advanced therapies: Promises and challenges

N Gallo, H Nasser, L Salvatore, ML Natali… - European Polymer …, 2019 - Elsevier
Hyaluronic acid (HA), also termed hyaluronan, is a key extracellular matrix
glycosaminoglycan that not only provides tissue hydration, but also shows intrinsic …

Regulation of non‐infectious lung injury, inflammation, and repair by the extracellular matrix glycosaminoglycan hyaluronan

D Jiang, J Liang, PW Noble - The Anatomical Record …, 2010 - Wiley Online Library
An important hallmark of tissue remodeling is the dynamic turnover of extracellular matrix
(ECM). ECM performs a variety of functions in tissue repair including scaffold formation …

Viscosity changes in hyaluronic acid: irradiation and rheological studies

E Daar, L King, A Nisbet, RB Thorpe… - Applied Radiation and …, 2010 - Elsevier
Hyaluronic acid (HA) is a significant component of the extracellular matrix (ECM), particular
interest being shown herein in synovial fluid. The present study aims to investigate the …

Hyaluronic acid: redefining its role

G Abatangelo, V Vindigni, G Avruscio, L Pandis, P Brun - Cells, 2020 - mdpi.com
The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has
promoted new research impetus for biologists and, the clinical interest in several fields of …

Hyaluronan fragments produced during tissue injury: A signal amplifying the inflammatory response

A Avenoso, G Bruschetta, A D'Ascola… - Archives of biochemistry …, 2019 - Elsevier
Inflammation is a complex mechanism that plays a key role during diseases. Dynamic
features of the extracellular matrix (ECM), in particular, during phases of tissue inflammation …