Transcriptional rates are often estimated by fitting the distribution of mature mRNA numbers
measured using smFISH (single molecule fluorescence in situ hybridization) with the …

The snapshot distribution of mRNA counts per cell can be measured using single-molecule
fluorescence in situ hybridization or single-cell RNA sequencing. These distributions are …

The large variability in mRNA and protein levels found from both static and dynamic
measurements in single cells has been largely attributed to random periods of transcription …

Many models of gene expression do not explicitly incorporate a cell cycle description. Here,
we derive a theory describing how messenger RNA (mRNA) fluctuations for constitutive and …

Genetically identical cell populations exhibit considerable intercellular variation in the level
of a given protein or mRNA. Both intrinsic and extrinsic sources of noise drive this variability …

Fluorescent and luminescent proteins are often used as reporters of transcriptional activity.
Given the prevalence of noise in biochemical systems, the time-series data arising from …

Single-molecule RNA fluorescence in situ hybridization (smFISH) provides unparalleled
resolution in the measurement of the abundance and localization of nascent and mature …

The cell division cycle of eukaryotes is governed by a complex network of cyclin-dependent
protein kinases (CDKs) and auxiliary proteins that govern CDK activities. The control system …

A key challenge in modeling single-cell RNA-seq data is to capture the diversity of gene
expression states regulated by different transcriptional regulatory inputs across individual …

Cells respond to their environment by modulating protein levels through mRNA transcription
and post-transcriptional control. Modest observed correlations between global steady-state …