A bio-based economy has the potential to provide sustainable substitutes for petroleum-
based products and new chemical building blocks for advanced materials. We previously …

Terpenes constitute a distinct class of natural products1 that attract insects, defend against
phytopathogenic microbes and combat human diseases. However, like most natural …

Microbial production of isoprene from renewable feedstock is a promising alternative to
traditional petroleum-based processes. Currently, efforts to improve isoprenoid production in …

Cannabis sativa L. has been cultivated and used around the globe for its medicinal
properties for millennia 1. Some cannabinoids, the hallmark constituents of Cannabis, and …

Highlights•Isoprenoids are industrially important natural products.•Yeast are key industrial
production vehicles.•New synthetic biology approaches in recent years are reviewed.•Future …

Throughout human history, natural products have been the foundation for the discovery and
development of therapeutics used to treat diseases ranging from cardiovascular disease to …

Isoprenoids are the most numerous and structurally diverse family of natural products.
Terpenoids, a class of isoprenoids often isolated from plants, are used as commercial flavor …

Current approaches for the production of high-value compounds in microorganisms mostly
use the cytosol as a general reaction vessel. However, competing pathways and metabolic …

Isoprenoids denote the largest group of chemicals in the plant kingdom and are employed
for a wide range of applications in the food and pharmaceutical industry. In recent years …

Amorphadiene, a sesquiterpene precursor to the anti-malarial drug artemisinin, is
synthesized by the cyclization of farnesyl pyrophosphate (FPP). Saccharomyces cerevisiae …