[HTML][HTML] Alcohol induces mitochondrial derangements in alveolar macrophages by upregulating NADPH oxidase 4
NL Morris, FL Harris, LAS Brown, SM Yeligar - Alcohol, 2021 - Elsevier
Excessive alcohol users have increased risk of developing respiratory infections in part due
to oxidative stress-induced alveolar macrophage (AM) phagocytic dysfunction. Chronic …
to oxidative stress-induced alveolar macrophage (AM) phagocytic dysfunction. Chronic …
[HTML][HTML] Pioglitazone reverses alcohol-induced alveolar macrophage phagocytic dysfunction
SM Yeligar, AJ Mehta, FL Harris… - The Journal of …, 2021 - journals.aai.org
Alcohol use disorders (AUD) increase susceptibility to respiratory infections by 2-to 4-fold in
part because of impaired alveolar macrophage (AM) immune function. Alcohol causes AM …
part because of impaired alveolar macrophage (AM) immune function. Alcohol causes AM …
Alcohol induced mitochondrial oxidative stress and alveolar macrophage dysfunction
Y Liang, FL Harris, LAS Brown - BioMed research international, 2014 - Wiley Online Library
An alcohol use disorder increases the risk of invasive and antimicrobial resistant community‐
acquired pneumonia and tuberculosis. Since the alveolar macrophage (AM) orchestrates …
acquired pneumonia and tuberculosis. Since the alveolar macrophage (AM) orchestrates …
Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction in alveolar type 2 cells
AA Alli, EM Brewer, DS Montgomery… - … of Physiology-Lung …, 2014 - journals.physiology.org
The lungs can undergo irreversible damage from chronic alcohol consumption. Herein, we
developed an animal model predisposed for edematous lung injury following chronic …
developed an animal model predisposed for edematous lung injury following chronic …
Peroxisome proliferator–activated receptor γ regulates chronic alcohol-induced alveolar macrophage dysfunction
SM Yeligar, AJ Mehta, FL Harris… - American journal of …, 2016 - atsjournals.org
Peroxisome proliferator–activated receptor (PPAR) γ is critical for alveolar macrophage (AM)
function. Chronic alcohol abuse causes AM phagocytic dysfunction and susceptibility to …
function. Chronic alcohol abuse causes AM phagocytic dysfunction and susceptibility to …
Alcohol induces mitochondrial redox imbalance in alveolar macrophages
Y Liang, FL Harris, DP Jones, LAS Brown - Free Radical Biology and …, 2013 - Elsevier
Alcohol abuse suppresses the immune responses of alveolar macrophages (AMs) and
increases the risk of a respiratory infection via chronic oxidative stress and depletion of …
increases the risk of a respiratory infection via chronic oxidative stress and depletion of …
Alcohol-induced glycolytic shift in alveolar macrophages is mediated by hypoxia-inducible factor-1 alpha
NL Morris, DN Michael, KM Crotty, SS Chang… - Frontiers in …, 2022 - frontiersin.org
Excessive alcohol use increases the risk of developing respiratory infections partially due to
impaired alveolar macrophage (AM) phagocytic capacity. Previously, we showed that …
impaired alveolar macrophage (AM) phagocytic capacity. Previously, we showed that …
Ethanol induces oxidative stress in alveolar macrophages via upregulation of NADPH oxidases
SM Yeligar, FL Harris, CM Hart… - The Journal of …, 2012 - journals.aai.org
Chronic alcohol abuse is a comorbid variable of acute respiratory distress syndrome.
Previous studies showed that, in the lung, chronic alcohol consumption increased oxidative …
Previous studies showed that, in the lung, chronic alcohol consumption increased oxidative …
Mitochondrial dysfunction: at the nexus between alcohol-associated immunometabolic dysregulation and tissue injury
RW Siggins, PM McTernan, L Simon… - International Journal of …, 2023 - mdpi.com
Alcohol misuse, directly or indirectly as a result of its metabolism, negatively impacts most
tissues, including four with critical roles in energy metabolism regulation: the liver, pancreas …
tissues, including four with critical roles in energy metabolism regulation: the liver, pancreas …
[HTML][HTML] Alcohol-induced mitochondrial DNA damage promotes injurious crosstalk between alveolar epithelial cells and alveolar macrophages
RT Sadikot, B Bedi, J Li, SM Yeligar - Alcohol, 2019 - Elsevier
Excessive alcohol users have a higher risk for developing respiratory infections compared to
individuals who do not chronically misuse alcohol, due to impaired host immune defense. In …
individuals who do not chronically misuse alcohol, due to impaired host immune defense. In …
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