Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities

C Lee, R Verma, S Byun, EJ Jeun, GC Kim… - Nature …, 2021 - nature.com
Yeast is an integral part of mammalian microbiome, and like commensal bacteria, has the
potential of being harnessed to influence immunity in clinical settings. However, functional …

Molecular analysis of a short-term model of β-glucans-trained immunity highlights the accessory contribution of GM-CSF in priming mouse macrophages response

S Walachowski, G Tabouret, M Fabre… - Frontiers in …, 2017 - frontiersin.org
β-Glucans (BGs) are glucose polymers present in the fungal cell wall (CW) and, as such, are
recognized by innate immune cells as microbial-associated pattern through Dectin-1 …

New insight into the structure-dependent two-way immunomodulatory effects of water-soluble yeast β-glucan in macrophages

Z Zheng, Q Huang - Carbohydrate Polymers, 2022 - Elsevier
The immunomodulatory effects and signalling pathways of five water-soluble yeast β-glucan
fractions (WYG1–5) with different molecular weights (M w) and chain conformations were …

Triggering dectin-1-pathway alone is not sufficient to induce cytokine production by murine macrophages

S Walachowski, G Tabouret, G Foucras - PloS one, 2016 - journals.plos.org
β-glucans (BG) are abundant polysaccharides of the Saccharomyces cerevisiae cell wall (Sc
CW), an industry byproduct. They have immuno-stimulatory properties upon engagement of …

Candida albicans β-Glucan Differentiates Human Monocytes Into a Specific Subset of Macrophages

J Leonhardt, S Große, C Marx, F Siwczak… - Frontiers in …, 2018 - frontiersin.org
β-Glucan derived from cell walls of Candida albicans is a potent immune modulator. It has
been shown to induce trained immunity in monocytes via epigenetic and metabolic …

LC3-Associated Phagocytosis Is Required for Dendritic Cell Inflammatory Cytokine Response to Gut Commensal Yeast Saccharomyces cerevisiae

D Lamprinaki, G Beasy, A Zhekova… - Frontiers in …, 2017 - frontiersin.org
The human fungal microbiota known as mycobiota is increasingly recognized as a critical
factor in human gut health and disease. Non-pathogenic commensal yeasts such as …

Complex dietary polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes

R Gudi, N Perez, BM Johnson, MH Sofi, R Brown… - …, 2019 - Wiley Online Library
The dietary supplement and prebiotic values of β‐glucan‐rich products have been widely
recognized and dietary approaches for modulating autoimmunity have been increasingly …

A drug-sensitive genetic network masks fungi from the immune system

RT Wheeler, GR Fink - PLoS pathogens, 2006 - journals.plos.org
Fungal pathogens can be recognized by the immune system via their β-glucan, a potent
proinflammatory molecule that is present at high levels but is predominantly buried beneath …

Brewer's yeast polysaccharides—a review of their exquisite structural features and biomedical applications

R Bastos, PG Oliveira, VM Gaspar, JF Mano… - Carbohydrate …, 2022 - Elsevier
Recent advances on brewer's yeast cell wall polysaccharides have unraveled exquisite
structural features and diverse composition with (β1→ 3),(β1→ 6),(α1→ 4),(β 1→ 4)-mix …

Inhibition of dextran sodium sulfate-induced colitis in mice by baker's yeast polysaccharides

Y Sun, X Shi, X Zheng, S Nie, X Xu - Carbohydrate polymers, 2019 - Elsevier
Most of the reported yeast polysaccharides are a mixture of chitin, β-glucan and
mannoprotein, leading to different biological activities. Herein, we report the structures and …