Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery

S Saleem, RR Kannan - Cell death discovery, 2018 - nature.com
Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

Zebrafish as a model organism for neurodegenerative disease

K Chia, A Klingseisen, D Sieger… - Frontiers in molecular …, 2022 - frontiersin.org
The zebrafish is increasingly recognized as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …

Zebrafish and medaka: important animal models for human neurodegenerative diseases

J Wang, H Cao - International journal of molecular sciences, 2021 - mdpi.com
Animal models of human neurodegenerative disease have been investigated for several
decades. In recent years, zebrafish (Danio rerio) and medaka (Oryzias latipes) have become …

Modeling neurodegeneration in zebrafish

Y Xi, S Noble, M Ekker - Current neurology and neuroscience reports, 2011 - Springer
The zebrafish, Danio rerio, has been established as an excellent vertebrate model for the
study of developmental biology and gene function. It also has proven to be a valuable model …

Advances of zebrafish in neurodegenerative disease: from models to drug discovery

X Wang, JB Zhang, KJ He, F Wang… - Frontiers in Pharmacology, 2021 - frontiersin.org
Neurodegenerative disease (NDD), including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, are characterized by the progressive loss of neurons which …

Zebrafish models for translational neuroscience research: from tank to bedside

AM Stewart, O Braubach, J Spitsbergen, R Gerlai… - Trends in …, 2014 - cell.com
The zebrafish (Danio rerio) is emerging as a new important species for studying
mechanisms of brain function and dysfunction. Focusing on selected central nervous system …

Modeling neurodegenerative disorders in zebrafish

AA Bashirzade, KN Zabegalov, AD Volgin… - Neuroscience & …, 2022 - Elsevier
Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and
amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain …

Zebrafish—a model organism for studying the neurobiological mechanisms underlying cognitive brain aging and use of potential interventions

MM Adams, H Kafaligonul - Frontiers in cell and developmental …, 2018 - frontiersin.org
Classically, the zebrafish model organism has been used to elucidate the genetic and
cellular mechanisms related to development since the embryo forms and grows externally …

Using the zebrafish model for Alzheimer's disease research

M Newman, E Ebrahimie, M Lardelli - Frontiers in genetics, 2014 - frontiersin.org
Rodent models have been extensively used to investigate the cause and mechanisms
behind Alzheimer's disease. Despite many years of intensive research using these models …

Advances in zebrafish as a comprehensive model of mental disorders

L Wang, F Liu, Y Fang, J Ma, J Wang, L Qu… - Depression and …, 2023 - Wiley Online Library
As an important part in international disease, mental disorders seriously damage human
health and social stability, which show the complex pathogenesis and increasing incidence …