Comparative Study Between a Customized Bimodal Endoscope and a Benchtop Microscope for Quantitative Tissue Diagnosis

H Mehidine, B Devaux, P Varlet, D Abi Haidar - Frontiers in Oncology, 2022 - frontiersin.org
Nowadays, surgical removal remains the standard method to treat brain tumors. During
surgery, the neurosurgeon may encounter difficulties to delimitate tumor boundaries and the …

Optical signatures derived from deep UV to NIR excitation discriminates healthy samples from low and high grades glioma

H Mehidine, A Chalumeau, F Poulon, F Jamme… - Scientific Reports, 2019 - nature.com
Among all the tumors of the central nervous system (CNS), glioma are the most deadly and
the most malignant. Surgical resection is the standard therapeutic method to treat this type of …

Real-time Brain Tumor imaging with endogenous fluorophores: a diagnosis proof-of-concept study on fresh human samples

F Poulon, J Pallud, P Varlet, M Zanello, F Chretien… - Scientific reports, 2018 - nature.com
The primary line of therapy for high-grade brain tumor is surgical resection, however,
identifying tumor margins in vivo remains a major challenge. Despite the progress in …

Multimodal optical analysis discriminates freshly extracted human sample of gliomas, metastases and meningiomas from their appropriate controls

M Zanello, F Poulon, J Pallud, P Varlet, H Hamzeh… - Scientific Reports, 2017 - nature.com
Delineating tumor margins as accurately as possible is of primordial importance in surgical
oncology: extent of resection is associated with survival but respect of healthy surrounding …

Molecular changes tracking through multiscale fluorescence microscopy differentiate Meningioma grades and non-tumoral brain tissues

H Mehidine, M Refregiers, F Jamme, P Varlet… - Scientific Reports, 2021 - nature.com
Meningioma is the most common primary intracranial extra-axial tumor. Total surgical
removal is the standard therapeutic method to treat this type of brain tumors. However, the …

Detection of human brain tumor infiltration with multimodal multiscale optical analysis

F Poulon, C Metais, F Jamme… - Advanced …, 2017 - spiedigitallibrary.org
Brain tumor surgeries are facing major challenges to improve patients' quality of life. The
extent of resection while preserving surrounding eloquent brain areas is necessary to …

Multimodal imaging to explore endogenous fluorescence of fresh and fixed human healthy and tumor brain tissues

H Mehidine, M Sibai, F Poulon, J Pallud… - Journal of …, 2019 - Wiley Online Library
To complement a project toward label‐free optical biopsy and enhanced resection which the
overall goal is to develop a multimodal nonlinear endomicroscope, this multimodal …

[HTML][HTML] Label-free imaging of human brain tissue at subcellular resolution for potential rapid intra-operative assessment of glioma surgery

D Chen, DW Nauen, HC Park, D Li, W Yuan, A Li… - Theranostics, 2021 - ncbi.nlm.nih.gov
Background: Frozen section and smear preparation are the current standard for
intraoperative histopathology during cancer surgery. However, these methods are time …

An in vivo two photon fluorescence endomicroscopic probe based on a 2-axis electrothermal MEMS mirror

H Mehidine, L Pinot, M Li, F Bouvet… - … on Biomedical Optics, 2019 - opg.optica.org
Nowadays, the ability to diagnose brain tumors intraoperatively and to delineate their
margins, as accurately as possible, is of primordial importance during surgery. However, the …

Quantitative Endogenous Fluorescence Analysis Discriminates Glioblastoma Tumor through Visible and NIR Excitation

H Mehidine, E Kaadou Mouawad, P Varlet, B Devaux… - Photonics, 2023 - mdpi.com
Nowadays, the ability to diagnose brain tumors intraoperatively and delineate their margins,
as accurately as possible, is of primordial importance during surgery. However, the exact …