Antibiotic resistance in patients with cystic fibrosis: past, present, and future

EP Perikleous, D Gkentzi, A Bertzouanis, E Paraskakis… - Antibiotics, 2023 - mdpi.com
Patients with cystic fibrosis (CF) are repeatedly exposed to antibiotics, especially during the
pulmonary exacerbations of the disease. However, the available therapeutic strategies are …

[HTML][HTML] Defining antimicrobial resistance in cystic fibrosis

TJ Kidd, R Canton, M Ekkelenkamp, HK Johansen… - Journal of Cystic …, 2018 - Elsevier
Antimicrobial resistance (AMR) can present significant challenges in the treatment of cystic
fibrosis (CF) lung infections. In CF and other chronic diseases, AMR has a different profile …

Antimicrobial resistance in cystic fibrosis: Does it matter?

PA Flume, VJ Waters, SC Bell… - Journal of Cystic …, 2018 - cysticfibrosisjournal.com
The prevalence of antimicrobial resistance (AMR) is increasing and is a high priority
worldwide for interventions from antibiotic stewardship to new antibiotic development …

Multidrug–resistant organisms in cystic fibrosis: management and infection–control issues

V Waters, F Ratjen - Expert review of anti-infective therapy, 2006 - Taylor & Francis
Chronic infection and inflammation are the hallmarks of cystic fibrosis lung disease. As cystic
fibrosis patients are living longer owing to more intense treatment, multidrug-resistant …

Cystic fibrosis: recent insights into inhaled antibiotic treatment and future perspectives

G Taccetti, M Francalanci, G Pizzamiglio, B Messore… - Antibiotics, 2021 - mdpi.com
Although new inhaled antibiotics have profoundly improved respiratory diseases in cystic
fibrosis (CF) patients, lung infections are still the leading cause of death. Inhaled antibiotics …

Approach to resistant gram-negative bacterial pulmonary infections in patients with cystic fibrosis

RN Chernish, SD Aaron - Current opinion in pulmonary medicine, 2003 - journals.lww.com
Therapy for antibiotic-resistant bacterial infections in cystic fibrosis involves the use of new
laboratory methods (synergy testing or multiple-combination bactericidal testing) to optimize …

Reconciling antimicrobial susceptibility testing and clinical response in antimicrobial treatment of chronic cystic fibrosis lung infections

VJ Waters, TJ Kidd, R Canton… - Clinical Infectious …, 2019 - academic.oup.com
Median cystic fibrosis (CF) survival has increased dramatically over time due to several
factors, including greater availability and use of antimicrobial therapies. During the …

The problems of antibiotic resistance in cystic fibrosis and solutions

C López-Causapé, E Rojo-Molinero… - Expert review of …, 2015 - Taylor & Francis
Chronic respiratory infection is the main cause of morbidity and mortality in cystic fibrosis
(CF) patients. One of the hallmarks of these infections, led by the opportunistic pathogen …

[HTML][HTML] Treatment of lung infection in patients with cystic fibrosis: current and future strategies

G Döring, P Flume, H Heijerman, JS Elborn… - Journal of Cystic …, 2012 - Elsevier
In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main
cause of death. Treatment of lung disease to reduce the impact of infection, inflammation …

[HTML][HTML] Cystic fibrosis microbiology: Advances in antimicrobial therapy

V Waters, A Smyth - Journal of cystic fibrosis, 2015 - Elsevier
Much of the improvement in the survival of individuals with cystic fibrosis (CF) is due to
advancements in antimicrobial treatments. New aerosolized antibiotic formulations have …