Effects of N-substituted analogs of benztropine: diminished cocaine-like effects in dopamine transporter ligands
JL Katz, TA Kopajtic, GE Agoston… - Journal of Pharmacology …, 2004 - ASPET
Previous studies demonstrated that analogs of benztropine (BZT) possess high affinity for
the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects …
the dopamine transporter, inhibit dopamine uptake, but generally have behavioral effects …
Dopamine transporter binding without cocaine-like behavioral effects: synthesis and evaluation of benztropine analogs alone and in combination with cocaine in …
JL Katz, GE Agoston, KL Alling, RH Kline… - …, 2001 - Springer
Rationale: Previous SAR studies demonstrated that small halogen substitutions on the
diphenylether system of benztropine (BZT), such as a para-Cl group, retained high affinity at …
diphenylether system of benztropine (BZT), such as a para-Cl group, retained high affinity at …
N-substituted benztropine analogs: selective dopamine transporter ligands with a fast onset of action and minimal cocaine-like behavioral effects
SM Li, TA Kopajtic, MJ O'Callaghan, GE Agoston… - … of Pharmacology and …, 2011 - ASPET
Previous studies suggested that differences between the behavioral effects of cocaine and
analogs of benztropine were related to the relatively slow onset of action of the latter …
analogs of benztropine were related to the relatively slow onset of action of the latter …
Discovery of drugs to treat cocaine dependence: behavioral and neurochemical effects of atypical dopamine transport inhibitors
Stimulant drugs acting at the dopamine transporter (DAT), like cocaine, are widely abused,
yet effective medical treatments for this abuse have not been found. Analogs of benztropine …
yet effective medical treatments for this abuse have not been found. Analogs of benztropine …
Assessment of the influence of histaminergic actions on cocaine-like effects of 3α-diphenylmethoxytropane analogs
VC Campbell, TA Kopajtic, AH Newman… - Journal of Pharmacology …, 2005 - ASPET
Previous studies demonstrated that analogs of benztropine (BZT) possess high affinity for
the dopamine (DA) transporter (DAT) but generally have behavioral effects different from …
the dopamine (DA) transporter (DAT) but generally have behavioral effects different from …
3 '-Chloro-3α-(diphenylmethoxy) tropane but not 4 '-chloro-3α-(diphenylmethoxy) tropane produces a cocaine-like behavioral profile
RH Kline, S Izenwasser, JL Katz… - Journal of medicinal …, 1997 - ACS Publications
A series of 2 '-and 3 '-substituted and 3 ', 3 ''-disubstituted 3α-(diphenylmethoxy) tropane
analogs were designed and synthesized as novel probes for the dopamine transporter. All …
analogs were designed and synthesized as novel probes for the dopamine transporter. All …
3'-and 4'-chloro-substituted analogs of benztropine: intravenous self-administration and in vitro radioligand binding studies in rhesus monkeys
WL Woolverton, JK Rowlett, KM Wilcox, IA Paul… - …, 2000 - Springer
Rationale: The reinforcing effects of many psychomotor stimulants have been related to
increased dopaminergic neurotransmission. Drugs that block dopamine (DA) uptake have …
increased dopaminergic neurotransmission. Drugs that block dopamine (DA) uptake have …
Structure−Activity Relationships at Monoamine Transporters and Muscarinic Receptors for N-Substituted-3α-(3'-chloro-, 4'-chloro-, and 4',4' '-dichloro-substituted …
The design, synthesis, and evaluation of 3α-(diphenylmethoxy) tropane (benztropine)
analogues have provided potent and selective probes for the dopamine transporter …
analogues have provided potent and selective probes for the dopamine transporter …
Therapeutic-like properties of a dopamine uptake inhibitor in animal models of amphetamine addiction
C Velazquez-Sanchez, A Ferragud… - International journal …, 2011 - academic.oup.com
N-substituted benztropine (BZT) analogs are molecules that display high affinity for the
dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and …
dopamine transporter (DAT), therapeutic-like effects in animal models of cocaine abuse, and …
Pharmacological characterization of a dopamine transporter ligand that functions as a cocaine antagonist
An N-butyl analog of benztropine, JHW007 [N-(n-butyl)-3 α-[bis (4′-fluorophenyl) methoxy]-
tropane], binds to dopamine transporters (DAT) but has reduced cocaine-like behavioral …
tropane], binds to dopamine transporters (DAT) but has reduced cocaine-like behavioral …